Association of total bilirubin and indirect bilirubin content with metabolic syndrome among Kazakhs in Xinjiang.

BMC Endocrine Disorders
Hao HaoShu-xia Guo

Abstract

Some studies have shown that a high level of bilirubin is a protective factor against metabolic syndrome (MS), while a high level of transaminase is a risk factor for MS. However, the existing results are inconsistent and few cohort studies have been published. Using an ambispective cohort study, 565 Kazakhs from Xinjiang, China were selected as the study subjects. The baseline serum bilirubin and transaminase levels of the subjects were divided into quartiles and the relationship between these values and the incidence of MS was analyzed. The definition of MS was based on the Joint Interim Statement (JIS) diagnostic criteria. The average follow-up time for the subjects was 5.72 years. The cumulative incidence of MS was 36.11% (204 of the 565 subjects), and the incidence density was 63.10/1000 person-years. Multivariate Cox regression analysis showed that the levels of total bilirubin (TBIL) and indirect bilirubin (IBIL) were negatively correlated with the occurrence of MS, Compared to the lowest quartile level (Q1), the hazard ratios of MS the TBIL levels at the Q2-Q4 quartiles were: 0.47 (0.31-0.71), 0.53 (0.35-0.79), and 0.48 (0.32-0.72), respectively, while IBIL levels at the Q2-Q4 quartiles showed an MS hazard ratio of 0.48...Continue Reading

References

Jun 16, 2009·Biochemical and Biophysical Research Communications·Graciela Luján MazzoneClaudio Tiribelli
Jun 9, 2015·The American Journal of Medicine·Jennifer Juxiang HuangJoseph S Alpert
Oct 30, 2016·Journal of Clinical Laboratory Analysis·You-Fan PengGui-Dan Xu
Apr 20, 2016·International Journal of Environmental Research and Public Health·Xiang-Hui ZhangShu-Xia Guo
Aug 16, 2016·Trends in Molecular Medicine·Silvia GazzinClaudio Tiribelli
Nov 7, 2017·Toxicological Sciences : an Official Journal of the Society of Toxicology·Donna L MendrickFlorence G Burleson
Dec 16, 2017·Clinics in Dermatology·Emma McCrackenShiva Sreenivasan
Feb 3, 2018·The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology·Seok Hoon LeeKyu Nam Kim
Jul 10, 2018·Transplantation Reviews·Vikram L SundararaghavanTerry D Hinds
Feb 12, 2019·Diabetology & Metabolic Syndrome·Makoto ShiraishiMichiaki Fukui
Jun 14, 2019·Oxidative Medicine and Cellular Longevity·Rosa VonaDonatella Pietraforte
Jul 25, 2019·Diabetes & Metabolic Syndrome·Ryuichi KawamotoTeru Kumagi

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.