Association of TP53 polymorphisms with primary open-angle glaucoma: a meta-analysis

Investigative Ophthalmology & Visual Science
Yatu GuoKanxing Zhao

Abstract

To offer a comprehensive evaluation of the potential associations of TP53 polymorphisms with primary open-angle glaucoma (POAG) through a systematic review and meta-analysis of candidate genetic association study. Medline, Embase, Science Citation Index, the Cochrane Library, and other databases (up to January 20, 2012) were searched by two investigators independently. Pooled odd ratios (ORs) and 95% confidence interval (CI) were used to assess the strength of the associations between two TP53 polymorphisms (codon 72 in exon 4 and 16 base-pair [bp] insertion in intron 3) and POAG. Statistical analysis was performed with a commercial statistical and data analysis software package. Nine independent studies on TP codon 72 (1930 cases and 1463 controls) and four articles on TP intron 3 16-bp insertion (858 cases and 683 controls) were identified. The overall results showed that there was significant association between TP53 codon 72 genotype and POAG risk in the recessive model (OR = 1.31, 95% CI 1.05-1.64, P = 0.017). Also, our analysis suggested that TP53 intron 3 16-bp insertion polymorphism was associated with decreased POAG risk in overall population when examining the contrast of Ins versus Del (OR 0.75, 95% CI = 0.57-0.97, P...Continue Reading

Citations

Aug 26, 2014·Current Opinion in Genetics & Development·Miook Cho, Yousin Suh
Sep 17, 2020·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Hamidreza MoazzeniElahe Elahi
Jun 30, 2012·Clinical Chemistry and Laboratory Medicine : CCLM·Haris KokotasGeorge Kitsos
Aug 12, 2020·Vestnik oftalmologii·D I Svinareva, M I Churnosov
Aug 21, 2019·BioMed Research International·Zhongjing LinYisheng Zhong
Dec 14, 2018·Frontiers in Neuroscience·Marita Pietrucha-DutczakAdrian Smedowski
Oct 28, 2017·Frontiers in Genetics·Hanan A AlkoziJesús J Pintor

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