Association of tubal factor infertility with elevated antibodies to Chlamydia trachomatis caseinolytic protease P.

American Journal of Obstetrics and Gynecology
Allison K RodgersGuangming Zhong

Abstract

The objective of the study was to assess antibodies against Chlamydia trachomatis heat shock proteins (HSP) in patients with tubal factor infertility (TFI), infertility controls (IFC), and fertile controls (FC). HSPs assist organisms in surviving caustic environments such as heat. Twenty-one TFI, 15 IFC, and 29 FC patients were enrolled after laparoscopic tubal assessment. The titers of antibodies against C trachomatis organisms and 14 chlamydial HSPs were compared among the 3 groups. TFI patients developed significantly higher levels of antibodies against C trachomatis and specifically recognizing chlamydial HSP60 and caseinolytic protease (Clp) P, a subunit of the ATP-dependent Clp protease complex involved in the degradation of abnormal proteins. In addition to confirming high titers of antibodies against C trachomatis organisms and HSP60 in TFI patients, we identified a novel link of TFI with anti-ClpP antibodies. These findings may provide useful information for developing a noninvasive screening test for TFI and constructing subunit anti-C trachomatis vaccines.

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Citations

Jul 31, 2012·Archives of Gynecology and Obstetrics·Arif KokcuDevran Bildircin
Dec 3, 2010·Current Opinion in Infectious Diseases·Sarah E M HowieGary Entrican
Sep 29, 2011·Infectious Diseases in Obstetrics and Gynecology·Amanda J StephensDanny J Schust
Oct 19, 2011·Clinical & Developmental Immunology·Kadri Haller-KikkataloRaivo Uibo
Jan 15, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A ArsovicD Baskic
Oct 12, 2011·The Journal of Experimental Medicine·Laszlo KariHarlan D Caldwell
Jul 12, 2011·Fertility and Sterility·Allison K RodgersGuangming Zhong
Apr 1, 2015·Infection and Immunity·Xin SunGanqiu Wu
Aug 11, 2017·PloS One·Yuyang ZhangGuangming Zhong
Mar 13, 2019·Infection and Immunity·Tianyuan ZhangGuangming Zhong
Jan 29, 2020·Infection and Immunity·Qi TianGuangming Zhong
Jun 14, 2020·Pathogens and Disease·Chunmin HuYuanjun Liu
Aug 5, 2020·Infection and Immunity·Lingxiang XieGuangming Zhong
Apr 2, 2020·Journal of Medicinal Chemistry·Mohamed A SeleemMartin Conda-Sheridan
Jul 20, 2021·Infection and Immunity·Zengzi ZhouGuangming Zhong

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