Association of Tubular Solute Clearance with Symptom Burden in Incident Peritoneal Dialysis.

Clinical Journal of the American Society of Nephrology : CJASN
Ke WangBryan R Kestenbaum

Abstract

Residual kidney function is important to the health and wellbeing of patients with ESKD. We tested whether the kidney clearances of proximal tubular secretory solutes are associated with burden of uremic and heart failure symptoms among patients on peritoneal dialysis with residual kidney function. We enrolled 29 patients on incident peritoneal dialysis with residual urine output >250 ml daily. We used targeted liquid chromatography-mass spectrometry to quantify plasma, 24-hour urine, and peritoneal dialysate concentrations of ten tubular secretory solutes. We calculated the kidney and peritoneal dialysis clearances of each secretory solute, creatinine, and urea, and we estimated a composite kidney and peritoneal secretion score. We assessed for uremic symptoms using the Dialysis Symptom Index and heart failure-related symptoms using the Kansas City Cardiomyopathy Questionnaire. We used linear regression to determine associations of composite secretory solute clearances and GFRurea+Cr with Dialysis Symptom Index symptom score and Kansas City Cardiomyopathy Questionnaire summary score. Mean residual kidney clearances of creatinine and urea were 8±5 and 9±6 ml/min per 1.73 m2, respectively, and mean GFRurea+Cr was 8±5 ml/min per ...Continue Reading

References

Jan 25, 1984·Biochimica Et Biophysica Acta·L M KarnitzL M Henderson
Dec 1, 1995·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·R W van OldenL Arisz
Apr 12, 2000·Journal of the American College of Cardiology·C P GreenJ A Spertus
Mar 7, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Jun 30, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D SheminL D Dworkin
Apr 23, 2002·Kidney International·Tsuneo DeguchiTetsuya Terasaki
May 31, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Fabian TermorshuizenUNKNOWN NECOSAD Study Group
Mar 11, 2004·Journal of Pain and Symptom Management·Steven D WeisbordGalen E Switzer
May 10, 2005·The Journal of Pharmacology and Experimental Therapeutics·Tsuneo DeguchiMasaki Otagiri
Feb 21, 2006·Journal of the American College of Cardiology·Paul A HeidenreichUNKNOWN Cardiovascular Outcomes Research Consortium
Apr 14, 2006·Kidney International·A Y-M Wang, K-N Lai
Nov 30, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Nhat M PhamTimothy W Meyer
Apr 5, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Bengt Rippe
Oct 30, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Ilian O MarquezTimothy W Meyer
Dec 29, 2010·Journal of Cardiac Failure·Michael G ShlipakUNKNOWN CRIC Investigators
Feb 10, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Yohei MiyamotoToru Maruyama
May 26, 2012·Journal of the American Society of Nephrology : JASN·Flore DurantonUNKNOWN European Uremic Toxin Work Group
May 3, 2013·Kidney International·Tammy L SirichTimothy W Meyer
Nov 16, 2013·Journal of the American Society of Nephrology : JASN·Tammy L SirichTimothy W Meyer
May 2, 2014·Seminars in Nephrology·Tammy L SirichToshimitsu Niwa
Nov 29, 2015·Journal of the American Society of Nephrology : JASN·Astrid M Suchy-DiceyBryan R Kestenbaum
Jul 23, 2016·Journal of the American Society of Nephrology : JASN·Manjula Kurella TamuraUNKNOWN FHN Study

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Jul 9, 2021·Clinical Journal of the American Society of Nephrology : CJASN·Lakshmi L GanesanTimothy W Meyer

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