Association of tumor necrosis factor alpha and IL-10 promoter polymorphisms with rheumatoid arthritis in North Indian population

Rheumatology International
Deepali GambhirSita Naik

Abstract

Rheumatoid arthritis is a chronic autoimmune disorder associated with altered expression of pro- and anti-inflammatory cytokines in the affected tissues. The aim of this study was to investigate the association between promoter polymorphisms of TNFalpha and IL-10 gene with susceptibility, age of disease onset and disease severity in North Indian patients with rheumatoid arthritis (RA). SNPs at position -308 and -863 of TNF gene and -819/-592 and -1082 position of IL-10 gene were determined in 222 patients and 208 healthy controls using RFLP or ARMS method. Polymorphism TNF -308A was less prevalent among the patients (1.7%) than controls (4.9%; p = 0.01, OR: 0.32, 95% CI: 0.13-0.76). Among female patients, IL-10 -592A allele associated with higher baseline disease activity scores (5.77 +/- 1.99) than -592C (5.57 +/- 1.19; p = 0.04). Female patients carrying allele A of TNFalpha -863 had earlier age of onset of RA (33.99 +/- 9.6 years) than those with allele C (36.15 +/- 11.21 years; p = 0.043). In conclusion, allele A at TNFalpha -308 locus provides protection against RA in North Indian population while another TNF allele A at -863 position had weak association with earlier onset of disease in female patients. On the other hand ...Continue Reading

References

Nov 8, 2012·International Journal of Rheumatology·A ScardapaneF Chiarelli
Jul 28, 2011·Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders·Hannan Al-RayesMohammad Tariq
Dec 7, 2013·Rheumatology International·Gwan Gyu SongYoung Ho Lee
Mar 31, 2012·Clinical Immunology : the Official Journal of the Clinical Immunology Society·S R HofmannC M Hedrich
Jan 30, 2015·Revista brasileira de reumatologia·Patricia Hartstein Salim, Ricardo Machado Xavier
Feb 7, 2018·Molecular Biology Reports·Daniel Cadena-SandovalJulián Ramírez-Bello
Feb 11, 2014·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Maha H El SissySherif Elanwary
Sep 22, 2016·SpringerPlus·Radwa R El-TahanNoha El-Mashad

Citations

May 1, 1992·British Journal of Rheumatology·F M BrennanM Feldmann
Feb 1, 1992·Arthritis and Rheumatism·A SilmanP Brennan
Jun 26, 1995·Biochemical and Biophysical Research Communications·A HamannJ S Flier
Jan 1, 1994·Immunogenetics·S D'Alfonso, P M Richiardi
Jan 18, 1997·Lancet·R G WestendorpJ P Vandenbrouke
May 8, 1998·Scandinavian Journal of Rheumatology·A H HajeerW E Ollier
Oct 20, 1998·Arthritis and Rheumatism·A M van GestelP L van Riel
Oct 23, 1998·British Journal of Rheumatology·G CoakleyJ Lanchbury
May 27, 1999·Annals of the Rheumatic Diseases·T UshiyamaS Hukuda
Jun 23, 1999·Rheumatology·F M Brennan
Nov 21, 2000·Rheumatology·T W HuizingaC L Verweij
Nov 30, 2000·Molecular and Cellular Biology·I A UdalovaD Kwiatkowski
Mar 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A W GibsonR P Kimberly
Mar 28, 2002·Human Immunology·Ritika JainiNarinder K Mehra
Feb 20, 2004·Genes and Immunity·J-P BayleyC L Verweij
May 27, 2006·American Journal of Respiratory Cell and Molecular Biology·Shilpy SharmaBalaram Ghosh

Related Concepts

Necrosis
IL10 wt Allele
Tumor Necrosis Factor-alpha
Restriction Fragment Length Polymorphism
Recombinant Interleukin-10
Anti-Inflammatory Agents
Promoter
Interleukin-10 Binding Activity
Human Interleukin-10 (Nonglycosylated)
Rheumatoid Arthritis

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