Association of tumor necrosis factor and human leukocyte antigen DRB1 alleles with Graves' ophthalmopathy

Human Immunology
T BednarczukJ Nauman

Abstract

Tumor necrosis factor (TNF)-alpha plays a central role in the development of ophthalmopathy in patients with Graves' disease (GD). The aim of this study was to investigate the association of TNF promoter polymorphisms at positions -1031 (T-1031C), -863 (C-863A), -857 (C-857T), -308 (G-308A), and -238 (G-238A) with Graves' ophthalmopathy (GO). We studied the distribution of TNF and human leukocyte antigen (HLA) DRB1 alleles in 228 Polish white patients with GD, 106 of whom had ophthalmopathy (NOSPECS class > or = III) and 248 healthy subjects. TNF -308A and HLA-DRB1*03 alleles were significantly increased in patients with GD compared with healthy subjects. Stratification analysis revealed no independent association of -308A with GD when the DRB1*03 status was considered. Subdividing GD according to eye involvement revealed that the distribution of TNF promoter haplotypes differed significantly in patients with or without ophthalmopathy. The haplotype containing the -238A allele was absent in GO. The association of G-238A with GO was independent of DRB1 alleles. These results indicate that TNF G-308A is associated with susceptibility to GD (however, this association is not independent of HLA-DRB1*03) and that TNF G-238A is associ...Continue Reading

References

Oct 1, 1995·Scandinavian Journal of Immunology·F PociotP M Richiardi
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·A G WilsonG W Duff
Jun 12, 1998·Thyroid : Official Journal of the American Thyroid Association·N R Farid, C Balazs
Sep 6, 2000·Clinical and Experimental Immunology·I M WakelkampW M Wiersinga
Oct 21, 2000·Thyroid : Official Journal of the American Thyroid Association·R VillanuevaT F Davies
Nov 9, 2000·The New England Journal of Medicine·A P Weetman
Mar 20, 2001·American Journal of Human Genetics·M StephensP Donnelly
Feb 19, 2002·Clinical Endocrinology·R VillanuevaT F Davies
Dec 6, 2002·The Journal of Clinical Endocrinology and Metabolism·Bijayeswar VaidyaSimon H S Pearce
Dec 17, 2002·Arthritis and Rheumatism·Eleftheria ZegginiUNKNOWN British Paediatric Rheumatology Study Group
May 3, 2003·The Journal of Clinical Endocrinology and Metabolism·Rebecca S Bahn
Sep 13, 2003·The Journal of Clinical Endocrinology and Metabolism·Seema Kumar, Rebecca S Bahn
May 1, 1956·Annals of Human Genetics·J B HALDANE
Oct 24, 2003·American Journal of Human Genetics·Matthew Stephens, Peter Donnelly
Dec 19, 2003·Human Molecular Genetics·Hyoung Doo ShinChoon-Sik Park
Feb 12, 2004·Arthritis and Rheumatism·Hiroe SatoKenneth I Welsh

❮ Previous
Next ❯

Citations

Oct 21, 2010·Endocrine·Mehdi AnvariAliakbar Amirzargar
Nov 11, 2005·Thyroid : Official Journal of the American Thyroid Association·Alina KurylowiczTomasz Bednarczuk
Mar 31, 2006·Thyroid : Official Journal of the American Thyroid Association·Tokunori MukaiTomasz Bednarczuk
Jun 8, 2006·Thyroid : Official Journal of the American Thyroid Association·Dorota KulaBarbara Jarzab
Mar 21, 2008·Thyroid : Official Journal of the American Thyroid Association·Patricia Mitiko Santello AkaishiEduardo Antonio Donadi
Jun 27, 2008·Thyroid : Official Journal of the American Thyroid Association·Michiko IchimuraYuji Hiromatsu
Jul 26, 2014·PloS One·Beata Jurecka-LubienieckaBarbara Jarzab
Jan 18, 2016·Advances in Medical Sciences·Aleksandra Sałagacka-KubiakEwa Balcerczak
May 29, 2012·Best Practice & Research. Clinical Endocrinology & Metabolism·Chiaw-Ling ChngDaphne Hsu Chin Khoo
May 25, 2007·Clinical Endocrinology·Tomasz BednarczukJack R Wall
Nov 23, 2006·International Journal of Immunogenetics·S N DasV Kapuria
Jun 30, 2015·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Piotr MiskiewiczTomasz Bednarczuk
Oct 9, 2009·Immunological Investigations·Manuela DittmarGeorge J Kahaly
Nov 8, 2008·Annals of Human Biology·Maha Kammoun-KrichenHammadi Ayadi
Mar 5, 2016·PloS One·Beata Jurecka-LubienieckaBarbara Jarzab
Mar 31, 2021·Ophthalmic Plastic and Reconstructive Surgery·Bo-Yeon KimChul-Hee Kim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.