Association of two ERCC4 tagSNPs with susceptibility to atrophic gastritis and gastric cancer in Chinese

Gene
Yantao GongYuan Yuan

Abstract

Genetic polymorphisms in excision repair cross-complementing group 4 (ERCC4) may contribute to the risk of cancer development. However, there are few reports regarding to susceptibility to gastric cancer (GC) or its precursor, atrophic gastritis (AG). Thereby, we investigated the association between two tag single nucleotide polymorphisms (tagSNPs) rs6498486 and rs254942, which represents the majority of common SNPs of ERCC4 gene, and the risks of GC and AG development in a sex- and age-matched case-control designed study. We found that rs6498486 polymorphism was associated with a reduced AG risk in total population (for AC vs. AA: OR=0.69, 95%CI=0.52-0.94, P=0.016; for AC/CC vs. AA: OR=0.68, 95%CI=0.51-0.92, P=0.010) as well as in the subpopulation of youngers (age<60years) (for AC/CC vs. AA: OR=0.67, 95%CI=0.45-0.99, P=0.048). For the rs254942 polymorphism, compared with the common TT genotype, the genotypes of CT and CT/CC were only observed to reduce AG risk in the subgroups of males (for CT vs. TT: OR=0.64, 95%CI=0.45-0.90, P=0.012; for CT/CC vs. TT: OR=0.66, 95%CI=0.47-0.92, P=0.016) and youngers (for CT vs. TT: OR=0.72, 95%CI=0.53-0.97, P=0.035; for CT/CC vs. TT: OR=0.74, 95%CI=0.55-0.99, P=0.045). However, no significan...Continue Reading

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Citations

Apr 29, 2014·Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis·Jing-Wei LiuYuan Yuan
Dec 2, 2009·Molecular Cancer·Andrea WatsonDavid O Walterhouse
Mar 30, 2017·Expert Review of Gastroenterology & Hepatology·Yongzhan NieDaiming Fan
Apr 19, 2017·Oncotarget·Patricia Carrera-LasfuentesMaría Asunción García-González

Related Concepts

Ercc4 protein, mouse
Base Excision Repair
DNA Helix Destabilizing Proteins
Gastritis, Atrophic
Genetic Equilibrium
Retrospective Studies
Selection, Genetic
Hereditary Diffuse Gastric Cancer
Nested Case-Control Studies
Helicobacter pylori

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Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.