Association of type 2 diabetes with cyclooxygenase-mediated inflammation and oxidative stress in an elderly population

Circulation
Johanna HelmerssonSamar Basu

Abstract

Involvement of cyclooxygenase (COX)-mediated inflammation in type 2 diabetes has not been studied, and the association between cytokine-mediated inflammation and diabetes is not fully clarified. 15-Keto-dihydro-prostaglandin F2alpha (a metabolite of prostaglandin F2alpha and an indicator of COX-mediated inflammation), high-sensitivity C-reactive protein (CRP), serum amyloid protein A (SAA), 8-iso-PGF2alpha (a nonenzymatic, free radical product of arachidonic acid and an indicator of oxidative stress), and alpha-tocopherol were measured in a population-based sample of 77-year-old men (n=765), in which 112 men had type 2 diabetes. The inflammatory indicators were increased in men with diabetes (urinary 15-keto-dihydro-PGF2alpha, P<0.001, CRP and SAA, P<0.05). However, when adjusted for body mass index, waist circumference, or fasting insulin, no association was found between diabetes and CRP or SAA. The oxidative stress indicator 8-iso-PGF2alpha in urine was increased (P<0.01) in men with diabetes. Patients who were newly diagnosed with diabetes (<7 years since diagnosis) had increased urinary 15-keto-dihydro-PGF2alpha and decreased alpha-tocopherol, but 8-iso-PGF2alpha was unaltered. This is the first study to show that type 2 d...Continue Reading

References

Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·Jason D MorrowL Jackson Roberts
Jun 21, 1990·The New England Journal of Medicine·G DaviCarlo Patrono
Nov 1, 1989·Metabolism: Clinical and Experimental·D E McMillan
Jul 1, 1993·Journal of Internal Medicine·M OhrvallBengt Vessby
Apr 3, 1997·The New England Journal of Medicine·P M RidkerCharles H Hennekens
Nov 25, 1998·FEBS Letters·Samar Basu, M Eriksson
Dec 11, 1999·JAMA : the Journal of the American Medical Association·M VisserTamara B Harris
Mar 17, 2000·Free Radical Biology & Medicine·L Jackson Roberts, Jason D Morrow
Mar 20, 2001·JAMA : the Journal of the American Medical Association·E A MeagherGarret A FitzGerald
Jul 24, 2001·JAMA : the Journal of the American Medical Association·A D PradhanP M Ridker
Jun 4, 2002·European Heart Journal·A D Pradhan, P M Ridker
Jul 27, 2002·European Journal of Clinical Nutrition·P C Calder, R F Grimble

Citations

Feb 9, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Yulan ZhaoChew-Kiat Heng
Mar 5, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Nada SallamIsmail Laher
Mar 15, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Johanna HelmerssonSamar Basu
May 22, 2009·The British Journal of Nutrition·Elisabet RytterSamar Basu
Jun 24, 2010·The British Journal of Nutrition·Helena PeterssonSamar Basu
Dec 23, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Michael B Zimmermann, Isabelle Aeberli
Sep 24, 2013·Molecular BioSystems·Sompop BencharitJohn B Buse
May 16, 2008·The New England Journal of Medicine·Björn ZetheliusJohan Ärnlöv
Jan 15, 2005·Antioxidants & Redox Signaling·Samar Basu, Johanna Helmersson
Jul 4, 2012·Antioxidants & Redox Signaling·Samar BasuMarie-Paule Vasson
Feb 14, 2006·Diabetes Technology & Therapeutics·Kevin A Deans, Naveed Sattar
Feb 14, 2006·Diabetes Technology & Therapeutics·Bruce B Duncan, Maria Inês Schmidt
Jan 20, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Gösta FlorvallAnders Larsson
Jun 27, 2008·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Anna-Maija TolppanenFinnish Diabetes Prevention Study Group
Oct 11, 2007·Diabetes, Obesity & Metabolism·Heather K VincentKevin R Vincent
Apr 6, 2005·Blood Purification·Leena MartolaP Stenvinkel
Apr 22, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Emanuela Ricciotti, Garret A FitzGerald
Oct 31, 2007·Circulation Research·Maritza J RomeroRobert W Caldwell
May 22, 2013·Chiropractic & Manual Therapies·David R Seaman
Oct 17, 2012·PloS One·Maciej S BuchowskiL Jackson Roberts
Jan 15, 2008·Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology·Jerard Kneifati-HayekRita Bellevue
Oct 25, 2007·Platelets·Nicoleta AlexandruManuela Amuzescu
Feb 18, 2006·Free Radical Research·Samar Basu
Sep 12, 2015·Journal of Internal Medicine·B SjöbergJohan Ärnlöv
Oct 9, 2012·Clinical Biochemistry·Johanna Helmersson-KarlqvistAnders Larsson
Jul 7, 2009·Diabetes Research and Clinical Practice·T ImatohH Une
Feb 24, 2009·The American Journal of Medicine·Yasuaki HayashinoTobias Kurth
Jan 14, 2009·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Dalma MénesiUndurti N Das
Jun 24, 2008·The Journal of Pediatrics·Javier Gómez-AmbrosiGema Frühbeck
Jun 2, 2004·EMBO Reports·Vicki Brower
Jun 21, 2005·International Journal of Clinical Practice·G I VarugheseG Y H Lip
Mar 9, 2005·Annals of the New York Academy of Sciences·Francesco VioliPasquale Pignatelli
Jul 4, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Janin HenkelGerhard P Püschel
Nov 22, 2008·European Journal of Clinical Investigation·P-S HsiehT-T Liu
Nov 24, 2006·Clinical Endocrinology·Rabih R AzarRoland Kassab
Jan 26, 2006·Gerodontology·Jukka H Meurman, Piia Hämäläinen
Jan 24, 2014·Geriatrics & Gerontology International·Kyung-Soo KimSeok Won Park
Mar 12, 2010·Diabetes/metabolism Research and Reviews·Agnès MathesonBradley J Walsh
Jun 20, 2006·The Journal of Nutritional Biochemistry·Alyssa H HastyJason D Morrow
Jul 19, 2006·Prostaglandins & Other Lipid Mediators·Johanna Helmersson, Samar Basu
Apr 25, 2006·Biochemical and Biophysical Research Communications·Chung-Yung J LeeBarry Halliwell
Apr 12, 2005·Advances in Chronic Kidney Disease·Nina Vasavada, Rajiv Agarwal
Oct 6, 2015·The Journal of Physiology·Mariam El AssarLeocadio Rodríguez-Mañas
Mar 19, 2014·Atherosclerosis·Johanna Helmersson-KarlqvistAnders Larsson
Aug 21, 2007·Redox Report : Communications in Free Radical Research·Samar BasuClaus G Krenn
Oct 8, 2014·Upsala Journal of Medical Sciences·Monica Sandberg, Leif Jansson
Apr 7, 2010·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Samar Basu
Jun 22, 2013·European Heart Journal·Johanna Helmersson-KarlqvistSamar Basu
Jul 3, 2009·Journal of Pharmacological Sciences·Takayuki MatsumotoKatsuo Kamata
Oct 30, 2016·European Journal of Preventive Cardiology·Axel C CarlssonJohan Ärnlöv
Aug 5, 2005·Angiology·Arvindan Veiraiah
Mar 31, 2018·Naunyn-Schmiedeberg's Archives of Pharmacology·Waleed BarakatSherif El-Kannishy
Dec 6, 2017·Research in Pharmaceutical Sciences·Rahimeh BargiMajid Khazaei
Aug 28, 2018·Journal of Cellular Physiology·Habib YaribeygiAmirhossein Sahebkar
Nov 4, 2004·European Journal of Clinical Nutrition·M D ParraJ A Martínez
Feb 11, 2014·Journal of the American Society of Nephrology : JASN·Axel C CarlssonJohan Ärnlöv
Jun 9, 2018·The International Journal of Neuroscience·Di GuoGuolin Wang
Jun 19, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Zsolt Bagi
Apr 13, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Adeel A ButtAbdul-Badi Abou-Samra
Jun 18, 2019·Pharmacological Reports : PR·Bina K Mehta, Sugato Banerjee
Feb 6, 2016·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Jie DongYuan Chen
Mar 25, 2010·The Journal of Clinical Endocrinology and Metabolism·Håkan MelhusKarl Michaëlsson
Mar 9, 2013·Acta Ophthalmologica·Sveinn Hakon Hardarson
Oct 7, 2006·The American Journal of Clinical Nutrition·Isabelle AeberliMichael B Zimmermann
Oct 5, 2017·Cell Biochemistry and Function·Elaheh ZafarvahedianMohammad Hossein Ghahremani
Aug 9, 2017·Clinical Journal of the American Society of Nephrology : CJASN·Axel C CarlssonJohan Ärnlöv
Sep 26, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Nóra ErdeiAkos Koller
Aug 24, 2018·Diabetes·Lale Ozcan, Ira Tabas
Dec 22, 2017·Journal of the Endocrine Society·Elizabeth MaW Timothy Garvey

Related Concepts

13,14-dihydro-15-ketoprostaglandin F
8-isoprostaglandin F2alpha
Amyloid Protein AA
Analgesics, Anti-Inflammatory
Zorprin
Blood Glucose
C-reactive protein
Diabetes Mellitus, Non-Insulin-Dependent
Inflammation
Novolin

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.