Association of type O blood with pancreatic neuroendocrine tumors in Von Hippel-Lindau syndrome.

Annals of Surgical Oncology
Allison B WeisbrodElectron Kebebew

Abstract

ABO blood type antigens are expressed not only on human red blood cells, but also throughout the gastrointestinal tract and in normal pancreatic tissue. Previous studies have identified an association between ABO blood type and various malignancies. We analyzed the association of ABO blood type with pancreatic neuroendocrine tumors (PNETs) in a high-risk cohort of patients with Von Hippel-Lindau (VHL) syndrome. A retrospective review was performed of 798 patients with VHL syndrome. Blood type was confirmed for 181 patients. Fisher's exact test and Mehta's modification to Fisher's exact test were used to test for an association between ABO blood type and manifestations of VHL syndrome. We found a strong trend for association between O blood type and pancreatic disease manifestation in patients with VHL syndrome (P = 0.047). More importantly, there was a significant association of O blood type with solid pancreatic lesions consistent with PNETs (P = 0.0084). Patients with solid pancreatic lesions who met criteria for surgical resection at the National Institutes of Health also had a higher rate of O blood type than those who did not require surgery (P = 0.051). Our findings suggest an association between O blood type and pancreat...Continue Reading

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Citations

Apr 1, 2016·Nature Reviews. Clinical Oncology·Xavier M KeutgenElectron Kebebew
Sep 8, 2016·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·D Rose Ewald, Susan C J Sumner
Jan 3, 2018·The Journal of Clinical Endocrinology and Metabolism·Amit TiroshElectron Kebebew
Aug 8, 2015·The Journal of Clinical Endocrinology and Metabolism·Sjoerd NellGerlof D Valk
May 13, 2018·Endocrine-related Cancer·Samuel M O'TooleWilliam M Drake
Oct 10, 2020·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Ophélie De RyckeLouis de Mestier

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