Association of Ulcerative Colitis with FUT2 and FUT3 Polymorphisms in Patients from Southeast China

PloS One
Ding-Yuan HuYi Jiang

Abstract

Dysbiosis of intestinal microbiota has been implicated in ulcerative colitis (UC). Fucosyltransferase (FUT) 2 and FUT3 determine expression of histo-blood group antigens in the gut and may affect the intestinal microbiota. We investigated the association between FUT2 and FUT3 polymorphisms and UC in Chinese patients. We genotyped FUT2 (rs281377, rs1047781 and rs601338) and FUT3 (rs28362459, rs3745635 and rs3894326) in 485 UC patients and 580 healthy controls using SNaPshot. We also evaluated expression of Lewis a and b antigens in the sigmoid colon of 7 UC patients and 7 patients with benign colonic polyps. The frequencies of mutant allele (A) and genotype (GA+AA) in FUT3 (rs3745635) were higher in UC patients than controls (P = 0.016, 95%CI: 1.339-1.699; P = 0.038, 95%CI: 1.330-1.742, respectively). Stratified analyses revealed that the frequencies of mutant allele (G) and genotype (TG+GG) of FUT3 (rs28362459) were significantly lower in patients with extensive colitis than those with distal colitis (P<0.001, 95%CI: 0.503-0.742; P = 0.001, 95%CI: 0.567-0.786, respectively). Similar conclusions were drawn for the mutant allele (A) and genotype (GA+AA) of FUT3 (rs3745635) in patients with extensive colitis compared to those with...Continue Reading

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Citations

Feb 16, 2018·Genes & Nutrition·S SurendranK S Vimaleswaran
Jun 11, 2017·Journal of Leukocyte Biology·Jennifer C BrazilCharles A Parkos
Nov 20, 2016·Diabetic Medicine : a Journal of the British Diabetic Association·K IharaUNKNOWN Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes (JSGIT)
Mar 29, 2019·Gastroenterology Research and Practice·Sheng-Long XiaYi Jiang
Dec 11, 2020·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·Mohammad FarahmandZabihollah Shoja
Jan 17, 2021·Viruses·Georges TarrisGaël Belliot
Dec 23, 2021·Cell Cycle·Xiaotian HuYingying Wang

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Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

SNaPshot
Haploview
Phase
Image Pro Plus
SPSS

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