Association of urokinase gene 3'-UTR polymorphism with calcium oxalate nephrolithiasis

Journal of Endourology
Rama Devi MittalM Bhandari

Abstract

Urokinase might play a role in the formation of kidney stones. The aim of this study was to investigate the role of the urokinase gene in calcium oxalate nephrolithiasis. A control group of 150 healthy individuals having no history of stone formation (mean age 40 +/- 11.5 years) and a group of 130 patients (mean age 40.5 +/- 10.5 years) with recurrent calcium oxalate stones were examined. The C/T polymorphism of the urokinase gene was detected using polymerase chain reaction (PCR)-based restriction analysis. A marginally significant difference (P = 0.035) was found in the distribution of the urokinase gene 3' untranslated region (UTR) C/T polymorphism between patients with stones and controls. The odds ratio for the risk of the T allele in stone patients was 1.006 (95% CI 0.63-1.62). The T allele of 3' UTR of the urokinase gene may not be associated with a higher risk of stone formation.

References

Oct 15, 1992·The New England Journal of Medicine·F L CoeJ R Asplin
Jan 1, 1992·Urological Research·C H van AswegenD J du Plessis
Dec 1, 1991·Medical Hypotheses·C H van Aswegen, D J du Plessis
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·P TripputiC M Croce
Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Mar 3, 1997·The Journal of Experimental Medicine·A R KitchingP G Tipping
Jan 1, 1997·World Journal of Urology·H O GoodmanR P Holmes
Jul 1, 1997·Medical Hypotheses·P J du ToitD J Du Plessis
Jul 16, 1999·Journal of Endourology·S V JackmanT W Jarrett
Nov 24, 1999·Molecular Medicine Today·P Y Kwok, Z Gu
Apr 25, 2000·The Urologic Clinics of North America·C J Danpure
Mar 1, 2005·Journal of Endourology·Hemant Kumar BidRama D Mittal

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Citations

Feb 2, 2008·International Urology and Nephrology·Murat OzturkBulent Oktay
Apr 1, 2008·Indian Journal of Clinical Biochemistry : IJCB·Rama D MittalRakesh Kapoor
Feb 18, 2011·Urologia Internationalis·Yiwei LinLiping Xie
Dec 19, 2009·Scandinavian Journal of Urology and Nephrology·Kuang-Chi LaiWen-Chi Chen

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