Association of Variants in BAG3 With Cardiomyopathy Outcomes in African American Individuals.

JAMA Cardiology
Valerie D MyersArthur M Feldman

Abstract

The prevalence of nonischemic dilated cardiomyopathy (DCM) is greater in individuals of African ancestry than in individuals of European ancestry. However, little is known about whether the difference in prevalence or outcomes is associated with functional genetic variants. We hypothesized that Bcl2-associated anthanogene 3 (BAG3) genetic variants were associated with outcomes in individuals of African ancestry with DCM. This multicohort study of the BAG3 genotype in patients of African ancestry with dilated cardiomyopathy uses DNA obtained from African American individuals enrolled in 3 clinical studies: the Genetic Risk Assessment of African Americans With Heart Failure (GRAHF) study; the Intervention in Myocarditis and Acute Cardiomyopathy Trial-2 (IMAC-2) study; and the Genetic Risk Assessment of Cardiac Events (GRACE) study. Samples of DNA were also acquired from the left ventricular myocardium of patients of African ancestry who underwent heart transplant at the University of Colorado and University of Pittsburgh. The primary end points were the prevalence of BAG3 mutations in African American individuals and event-free survival in participants harboring functional BAG3 mutations. Four BAG3 genetic variants were identifie...Continue Reading

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Citations

May 10, 2019·Journal of the American Heart Association·Jake M KiesermanArthur M Feldman
Oct 13, 2019·Nature Reviews. Cardiology·Andrew N RosenbaumNaveen L Pereira
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Sep 26, 2019·JAMA Cardiology
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Sep 7, 2021·Journal of Cellular Biochemistry·Thomas G MartinJonathan A Kirk
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