Association of variants of miRNA processing genes with cervical precancerous lesion risk in a southern Chinese population

Bioscience Reports
Shi-Qi HuangChun-Xia Jing

Abstract

The miRNA processing genes play essential roles in the biosynthesis of mammalian miRNAs, and their genetic variants are involved in the development of various cancers. Our study aimed to determine the potential association between miRNA processing gene polymorphisms and cervical precancerous lesions. Five single nucleotide polymorphisms (SNPs), including Ran-GTP (RAN) rs14035, exportin-5 (XPO5) rs11077, DICER1 rs3742330, DICER1 rs13078, and TARBP2 rs784567, were genotyped in a case-control study to estimate risk factors of cervical precancerous lesions. The gene-environment interactions and haplotype association were estimated. We identified a 27% decreased risk of cervical precancerous lesions for individuals with minor G allele in DICER1 rs3742330 (odds ratio (OR) = 0.73, 95% confidence interval (95% CI) = 0.58-0.92, P = 0.009). The AG and AG/GG genotypes in DICER1 rs3742330 were also found to decrease the risk of cervical precancerous lesions (AG compared with AA: OR = 0.51, 95% CI = 0.35-0.73, P <0.001; AG/GG compared with AA: OR = 0.54, 95% CI = 0.39-0.77, P = 0.001). The GT haplotype in DICER1 had a risk effect on cervical precancerous lesions compared with the AT haplotype (OR = 1.36, 95% CI = 1.08-1.73, P = 0.010). A tw...Continue Reading

References

Oct 1, 1989·American Journal of Public Health·M MaclureS R Tannenbaum
Jan 31, 1985·The New England Journal of Medicine·I M SassonS Nilsson
Apr 7, 1997·The Journal of Cell Biology·E IzaurraldeU Fischer
May 4, 2000·Journal of the National Cancer Institute·H zur Hausen
Jan 19, 2002·Science·Alicia E SmithIan G Macara
Apr 23, 2002·JAMA : the Journal of the American Medical Association·Diane SolomonUNKNOWN Bethesda 2001 Workshop
Jun 5, 2002·Nature Reviews. Cancer·Harald zur Hausen
Jul 10, 2002·Cancer Detection and Prevention·Ann L CokerLucia Pirisi
Jul 8, 2003·International Journal of Cancer. Journal International Du Cancer·Véronique DalsteinChristiane Mougin
Sep 26, 2003·Nature·Yoontae LeeV Narry Kim
Jul 21, 2004·Lancet·Julian PetoFiona E Matthews
Sep 17, 2004·Nature·Victor Ambros
Nov 9, 2004·Nature·Richard I GregoryRamin Shiekhattar
Feb 23, 2005·Cancer Science·Yoko KarubeTakashi Takahashi
Dec 20, 2005·The Journal of Pathology·Peter J F SnijdersChris J L M Meijer
Jan 18, 2006·Science·Ian J MacraeJennifer A Doudna
Dec 19, 2008·The New England Journal of Medicine·William M MerrittAnil K Sood
Feb 26, 2009·Cell·Richard W Carthew, Erik J Sontheimer
Jun 27, 2009·Science·D Ashley HillPaul J Goodfellow
Oct 24, 2009·Molecular Carcinogenesis·Jessica ClagueXifeng Wu
Jan 21, 2011·Indian Journal of Cancer·Y D ChankapaD Tsering
Feb 25, 2011·Cell Cycle·Sonia A Melo, Manel Esteller
Sep 19, 2012·Genes, Chromosomes & Cancer·Mariska BierkensRenske D M Steenbergen
Jan 7, 2014·Nature·Akinyemi I OjesinaMatthew Meyerson
Mar 29, 2014·Medical Oncology·Hongqin ZhaoCongying Xie
Jul 17, 2014·Nature Reviews. Molecular Cell Biology·Minju Ha, V Narry Kim
Aug 16, 2014·The Journal of Pathology·Marc ArbynJoakim Dillner
Sep 2, 2014·Nature Reviews. Cancer·William D FoulkesThomas F Duchaine
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Dec 22, 2015·BioMed Research International·Ewa Osuch-WojcikiewiczIreneusz Majsterek
Aug 9, 2016·World Journal of Urology·Z NikolićG Brajušković

❮ Previous
Next ❯

Citations

Sep 7, 2018·Genetic Testing and Molecular Biomarkers·Yao WangXiangcai Wei
May 2, 2019·Bioscience Reports·Yezhou LiuJinhai Jia
Feb 4, 2021·Experimental and Molecular Pathology·Jéssica Vilarinho CardosoJamila Alessandra Perini

❮ Previous
Next ❯

Methods Mentioned

BETA
GTPase
blood collection
Assay
reverse transcription PCR
PCR
genotyping

Software Mentioned

Typer
MassARRAY Assay Design
SPSS
MDR

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.