Association of variants of the TCF7L2 gene with increases in the risk of type 2 diabetes and the proinsulin:insulin ratio in the Spanish population.

Diabetologia
J L González-SánchezManuel Serrano-Ríos

Abstract

The gene encoding transcription factor 7-like 2 (TCF7L2) has been related to type 2 diabetes in multiple ethnic groups. Here, we investigate whether three single nucleotide polymorphisms (SNPs) in the TCF7L2 gene are associated with an impaired proinsulin:insulin ratio. In this study we examined the associations between SNPs rs7901695, rs7903146 and rs12255372 in the TCF7L2 gene and metabolic variables affecting type 2 diabetes in a population-based study of 706 unrelated individuals (47% men and 53% women; aged 35-74 years) from the province of Segovia in central Spain (Castille), including 180 individuals with type 2 diabetes. The minor allele frequency of rs7901695, rs7903146 and rs12255372 was significantly higher in diabetic patients compared with that in non-diabetic individuals. The T (minor) allele of the variant rs7903146 was significantly associated with a greater OR for type 2 diabetes adjusted for age, sex and BMI in logistic regression analysis: OR 1.29 (95% CI 1.06-1.57, p = 0.01). This risk allele was also associated with an increased proinsulin:insulin ratio after OGTT. Similar results were obtained for the other TCF7L2 SNPs. Our results provide further evidence supporting the belief that the TCF7L2 gene is a ma...Continue Reading

References

Oct 7, 2003·Annual Review of Genomics and Human Genetics·Jose C FlorezDavid Altshuler
Jan 18, 2006·Nature Genetics·Struan F A GrantKari Stefansson
Jul 21, 2006·The New England Journal of Medicine·Jose C FlorezUNKNOWN Diabetes Prevention Program Research Group
Jan 9, 2007·Nature Genetics·Agnar HelgasonKári Stefánsson
Apr 4, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ingrid C RulifsonSeung K Kim
May 4, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Stéphane CauchiPhilippe Froguel
Jun 15, 2007·Current Opinion in Clinical Nutrition and Metabolic Care·Jose C Florez
Aug 3, 2007·The Journal of Clinical Investigation·Valeriya LyssenkoLeif Groop
Feb 2, 2008·Obesity·Stéphane CauchiPhilippe Froguel
May 1, 2008·Current Diabetes Reports·Stéphane Cauchi, Philippe Froguel

❮ Previous
Next ❯

Citations

Aug 5, 2011·PloS One·Jeanne M McCafferyUNKNOWN Diabetes Prevention Program Research Group
Jul 13, 2014·Human Molecular Genetics·Yuedan ZhouOla Hansson
Apr 9, 2009·The Journal of Clinical Endocrinology and Metabolism·Assel BiyashevaMargrit Urbanek
Sep 24, 2015·International Journal of Environmental Research and Public Health·Hua YaoJun Zhu
Mar 10, 2009·Diabetes/metabolism Research and Reviews
Mar 9, 2011·Diabetes/metabolism Research and Reviews·Guenther SilbernagelBernhard O Boehm
Jun 28, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hyun-Jung ChoHyung-Gun Kim
Sep 1, 2015·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Yuzhi DingQinghuai Liu
Jan 30, 2015·Arquivos brasileiros de endocrinologia e metabologia·Taís S AssmannDaisy Crispim
Jan 9, 2013·Arquivos brasileiros de endocrinologia e metabologia·Gustavo Barcelos BarraAngélica Amorim Amato
Jul 1, 2009·Nature Reviews. Endocrinology·Elliot S Stolerman, Jose C Florez
Sep 15, 2009·Endocrine Reviews·Harald StaigerHans-Ulrich Häring
Sep 27, 2018·World Journal of Diabetes·Carolina BelosoAdriana Mimbacas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.