Association of vaspin rs2236242 gene variants with type 2 diabetes and obesity in a Chinese population: A prospective, single-center study

Journal of Cellular Physiology
Ji LiShou-Jun Bai

Abstract

Vaspin is an adipokine separated from visceral fat tissues of obese diabetic rats. This study was to investigate the association between vaspin rs2236242 gene polymorphism and type 2 diabetes mellitus (T2DM) or obesity in a Chinese population. T2DM patients and nondiabetic controls were recruited from Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University (Shanghai, China) from May 1, 2015 to June 30, 2017. Clinicopathologic characteristics were recorded and their blood samples were collected. Serum vaspin levels were detected by enzyme-linked immunosorbent assay and vaspin rs2236242 genotypes by tetra-amplification refractory mutation system-polymerase chain reaction. Two hundred and ninety-nine patients with T2DM and 311 controls were recruited at last. The vaspin genotypes of diabetic patients were distinct from nondiabetic controls (χ 2  = 54.611, p < 0.0001). Genotyping revealed that T2DM patients have a greater prevalence of A allele compared with controls (61.9% vs. 42.1%, p < 0.0001). A allele was associated with an increased risk of T2DM (odds ratio = 2.23, 95% confidence interval = 1.773-2.804, p < 0.0001) compared with T allele. The genotype distribution did not differ among nondiabetic subjects with or w...Continue Reading

References

Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Jul 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Kazuyuki HidaYashpal S Kanwar
Nov 22, 2005·Biochemical and Biophysical Research Communications·Nora KlötingMatthias Blüher
Nov 10, 2007·Diabetes·Byung-Soo YounMatthias Blüher
Jul 26, 2008·The Journal of International Medical Research·Q LiT Takahashi
Aug 30, 2008·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·K KempfC Vollmert
Oct 28, 2008·European Journal of Endocrinology·Nese Ersoz GulcelikAlper Gurlek
Sep 22, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A KörnerW Kiess
Mar 5, 2011·Biological & Pharmaceutical Bulletin·Hideyuki Yamawaki
Mar 16, 2012·Experimental Dermatology·Anja SaalbachJan C Simon
Nov 6, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hai Ling LiYa Wei Xu
Feb 2, 2013·Cellular and Molecular Life Sciences : CMLS·John T HeikerAnnette G Beck-Sickinger
Mar 19, 2013·The Biochemical Journal·Stephan SchultzAnnette G Beck-Sickinger

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Citations

Aug 14, 2020·Nutritional Neuroscience·Ping ZhangJinggui Song

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