Association of VEGFR-2 Gene Polymorphisms With Clopidogrel Resistance in Patients With Coronary Heart Disease

American Journal of Therapeutics
Li-Jun ZhangZhi-Qiang Zhang

Abstract

Vascular endothelial growth factor receptor 2 (VEGFR-2) plays a central role in atherogenesis. We investigated the correlation between VEGFR-2 polymorphisms and the risk of clopidogrel resistance (CR) in patients with coronary heart disease (CHD). The study involved 275 patients with CHD undergoing percutaneous coronary intervention and on antiplatelet clopidogrel therapy. The participants were divided into CR group (n = 59) and non-CR group (NCR, n = 216) based on maximum platelet aggregation measurements. VEGFR-2 gene polymorphisms, +1192C>T (rs2305948), +1416T>A (rs1870377), and -271A>G (rs7667298), were genotyped using polymerase chain reaction-restriction fragment length polymorphism. Enzyme-linked immunosorbent assay was used to measure serum transforming growth factor, beta receptor 2 levels. CR was found in 59 patients (20.45%). A significantly higher proportion of patients in the CR group had a history of diabetes mellitus compared with the NCR group (P < 0.05). Genotype and allele frequency of VEGFR-2 +1192C>T (rs2305948) was significantly higher in the CR group than in the NCR group (all P < 0.01). In the VEGFR-2 +1192C>T (rs2305948), the angina pectoris, recurrent myocardial infarction, and combined end point events...Continue Reading

References

May 30, 2002·Circulation·Karl B LemströmPetri K Koskinen
Jan 18, 2005·Journal of the American College of Cardiology·Victor L SerebruanyEric J Topol
Jul 13, 2006·Journal of Atherosclerosis and Thrombosis·Taro Matsumoto, Hideo Mugishima
Aug 30, 2006·Journal of Thrombosis and Haemostasis : JTH·D SibbingN von Beckerath
Apr 10, 2007·Journal of the American College of Cardiology·Dominick J AngiolilloMarco A Costa
Aug 21, 2007·Journal of the American College of Cardiology·Yibo WangRutai Hui
Dec 18, 2008·Annals of Medicine·Pieter W HolmRené A Tio
Aug 7, 2009·IUBMB Life·Edward Stuttfeld, Kurt Ballmer-Hofer
Jan 30, 2010·Current Problems in Cardiology·Thomas A GazianoAdrianna Murphy
Feb 4, 2011·Medical Hypotheses·Guixue WangTieyin Yin
Mar 17, 2011·JAMA : the Journal of the American Medical Association·Matthew J PriceUNKNOWN GRAVITAS Investigators
Jan 25, 2012·Journal of Thrombosis and Haemostasis : JTH·C LiJ W Eikelboom
Apr 19, 2012·Menopause : the Journal of the North American Menopause Society·HyungChul RahNam Keun Kim
Aug 25, 2012·Handbook of Experimental Pharmacology·Alexandre Kauskot, Marc F Hoylaerts
Sep 26, 2012·Current Pharmaceutical Design·Mirjam SchuchardtMarkus van der Giet
Nov 1, 2012·The International Journal of Neuroscience·Md Shariful HasanJohnson Stanslas
Dec 20, 2013·Circulation·Alan S GoUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Feb 11, 2014·International Journal of Cancer. Journal International Du Cancer·Mario ScartozziStefano Cascinu

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