Association of vitamin C with the risk of age-related cataract: a meta-analysis

Acta Ophthalmologica
Lin WeiJin Lv

Abstract

Whether vitamin C is a protective factor for age-related cataract remains unclear. Thus, we conducted a meta-analysis to summarize the evidence from epidemiological studies of vitamin C and the risk of age-related cataract. Pertinent studies were identified by searching in PubMed and in Webscience. The random effect model was used to combine the results. Meta-regression and subgroups analyses were used to explore potential sources of between-study heterogeneity. Publication bias was estimated using Egger's regression asymmetry test. Finally, 15 articles with 20 studies for vitamin C intake and eight articles with 10 studies for serum ascorbate were included in this meta-analysis. The relative risk (RR) and 95% confidence interval of cataract for the highest versus the lowest category of vitamin C intake was 0.814 (0.707-0.938), and the associations were significant in America and Asia. Significant association of cataract risk with highest versus the lowest category of serum ascorbate was found in general [0.704 (0.564-0.879)]. Inverse associations were also found between serum ascorbate and nuclear cataract and posterior subcapsular cataract. Higher vitamin C intake and serum ascorbate might be inversely associated with risk of...Continue Reading

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Citations

May 4, 2017·Nutrients·Alfredo García-LayanaFernando Arós
Jun 29, 2017·Ophthalmic Epidemiology·Sangshin Park, Nam-Kyong Choi
Oct 16, 2018·Current Opinion in Ophthalmology·Ruti Sella, Natalie A Afshari
Aug 5, 2017·Acta Ophthalmologica·Alon HarrisBrent Siesky
Sep 12, 2018·Nutrients·Manfred EggersdorferKatherine L Tucker
Oct 12, 2018·BMC Ophthalmology·Seung Wan NamTae-Young Chung
Oct 18, 2020·Nutrients·Julie C LimPaul J Donaldson
Aug 3, 2021·Experimental Eye Research·Tayler F L WishartFrank J Lovicu

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