Association of vitamin D deficiency with coronary artery disease in Mexican population: Genetics of atherosclerotic disease (GEA) study

Gaceta médica de México
Fabiola López-BautistaRosalinda Posadas-Sánchez

Abstract

To investigate the independent association between vitamin D deficiency (VDD) and coronary artery disease (CAD) in Mexican adult population. Matched case-control study. Data cardiovascular on risk factors, medication use, physical activity, alcohol use, smoking and vitamin D consumption were obtained. Biochemical variables, anthropometric and blood pressure were measured. 25(OH)D was quantified by chemiluminescence. We studied 250 patients with established CAD and 250 age-gender-body mass index (BMI) matched control subjects, with a mean age of 53 ± 6.1 years and BMI of 28 ± 3.5 kg/m2. Deficiency of 25(OH)D was significantly higher in the control group (21.2 vs. 16%). Multiple logistic regression analysis did not show association between VDD and CAD (OR: 1.37 [0.08-23.2]). Multiple linear regression analysis also showed that statin use (b = 2.2; p = 0.004) and no alcohol use (b = -1.8; p = 0.03) significantly increased 25(OH)D levels. No independent association between VDD and the presence of coronary artery disease was found in Mexican adult population. The results suggest that treatment with statins and absence of alcohol consumption, might be the explanation for the higher concentrations of 25(OH)D observed in patients with ...Continue Reading

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.

Related Papers

Anales de medicina interna : organo oficial de la Sociedad Española de Medicina Interna
P PlansL Salleras
The American Journal of Cardiology
April W ArmstrongEhrin J Armstrong
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
Hong-Ri LiGuo-Wei Song
© 2022 Meta ULC. All rights reserved