Association of Vitamin D Receptor BsmI Gene Polymorphism with BMD Z-Score in Iranian Children and Adolescents (9 - 18 Years Old)

International Journal of Endocrinology and Metabolism
Nima Montazeri-NajafabadyMahdi Akbarzadeh

Abstract

The vitamin D receptor (VDR) gene variants are known as the main risk factor for low bone mass. In this study, the association of vitamin D receptor genetic variants, BsmI (rs1544410) and FokI (rs2228570), with bone mass in Iranian children and adolescents, was evaluated. The study population comprised of children and adolescents aged between 9 to 18 years (FokI: 123 boys and 120 girls, BsmI: 108 boys and 110 girls). Vitamin D, calcium, phosphorus, total cholesterol (TC), High-density lipoprotein-cholesterol (HDL-C) and triglyceride (TG) concentrations were assayed. Bone mineral density and body composition parameters were measured by the Hologic system DXA. BMD Z-score ≤ -2 was considered as low bone density for chronologic age. PCR-restriction fragment length polymorphism was done for genotyping of BsmI and FokI polymorphisms. The association between VDR variants and bone mineral density was investigated using logistic regression analysis. No significant differences in body composition and biochemical parameters were detected among the evaluated VDR genotypes. For VDR BsmI, the mean values for Z-score of the lumbar spine, neck, inter and total femur was greater in the bb genotype compared to BB and Bb genotypes. Logistic regr...Continue Reading

References

Jun 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·B L RiggsJ A Eisman
Mar 1, 1997·Calcified Tissue International·R W KeenC Cooper
Jun 17, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S FerrariJ P Bonjour
May 13, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S K AmesS A Abrams
Aug 24, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L GennariM L Brandi
May 2, 2002·Journal of Bone and Mineral Metabolism·Kiyoe KatsumataAkifumi Tokita
Jul 25, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Marcia C WillingSteven M Levy
Apr 2, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Ammarin ThakkinstianJohn Attia
Mar 23, 2005·Archives of Disease in Childhood·J H DaviesJ W Gregory
Mar 28, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jose M Valdivielso, Elvira Fernandez
May 12, 2010·Journal of Bone and Mineral Metabolism·Xiao-Dan YuChong-Huai Yan
Aug 30, 2010·Archives of Medical Science : AMS·Azza A G TantawyShadia Ragab
Mar 17, 2012·Molecular Biology Reports·Elżbieta Jakubowska-PietkiewiczDanuta Chlebna-Sokół
Nov 9, 2012·Genetic Testing and Molecular Biomarkers·Fu JiaYing Xiong
Sep 26, 2013·Kidney & Blood Pressure Research·Melanie GlockeUndine E Lang
Nov 5, 2014·Journal of Diabetes and Metabolic Disorders·Zahra MohammadiHamid Reza Barikani
Dec 18, 2014·Journal of Bone and Mineral Metabolism·Elham AshouriMarzieh Bakhshayeshkaram
Jun 3, 2015·Nature Reviews. Endocrinology·Joshua N Farr, Sundeep Khosla
Aug 10, 2016·Journal of Clinical and Diagnostic Research : JCDR·Morteza Dehghan, Razieh Pourahmad-Jaktaji
Feb 24, 2017·Clinical Cases in Mineral and Bone Metabolism : the Official Journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases·Raheleh DabirniaEhsan Saburi

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
X-ray

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.