Association of vitamin D receptor BsmI rs1544410 and ApaI rs7975232 polymorphisms with susceptibility to adolescent idiopathic scoliosis: A systematic review and meta-analysis

Medicine
Xin YinShuxun Hou

Abstract

AIS is the most common spinal deformity disease, yet its etiology remains uncertain. Significant associations have been found between AIS risk and vitamin D receptor (VDR) gene polymorphisms; however, some of these results are controversial. The aim of this study was to determine whether VDR BsmI rs1544410 and ApaI rs7975232 polymorphisms are correlated with AIS. Databases, including PubMed, EMBASE, Web of Science, the Cochrane Library, the Chinese Biomedical Literature Database, and the Wanfang Database, were systematically searched, and eligible case-control studies that explored the association of VDR (BsmI and ApaI) and the susceptibility to AIS were selected. The pooled odds ratio (OR) with 95% confidence interval (95% CI) was calculated to assess the associations, and subgroup meta-analyses were performed according to the ethnicity of the study population. A total of 5 studies with 717 cases and 554 controls fulfilled the inclusion criteria after assessment by 2 reviewers. Generally, significant correlations were found between the BsmI polymorphism and AIS risk in overall populations and in Asian populations (overall population: B vs b: OR = 2.12, 95% CI = 1.21-3.75, P = .009; BB vs bb: OR = 3.38, 95% CI = 1.08-10.57, P =...Continue Reading

References

Mar 11, 1989·Nucleic Acids Research·J H FaracoP M Frossard
Jan 20, 1994·Nature·N A MorrisonJ A Eisman
Jan 1, 1996·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L M SalamoneJ A Cauley
Apr 3, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M R HausslerP W Jurutka
Aug 10, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J C ChengX Guo
Jul 3, 2002·American Journal of Human Genetics·Vivian ChanTai-Kwong Chan
Mar 19, 2003·Spine·Cristina M JusticeAlexander F Wilson
Aug 19, 2004·Gene·André G UitterlindenJohannes P T M Van Leeuwen
May 18, 2005·Spine·Nancy H MillerAlexander F Wilson
Sep 16, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Warren T K LeeJack Chun Yiu Cheng
May 6, 2008·Lancet·Stuart L WeinsteinJose A Morcuende
Aug 26, 2009·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Il-Soo EunJung Sub Lee
Apr 3, 2010·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Kuen Tak SuhJung Sub Lee
Jan 27, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Hurriyet YilmazOzturk Ozdemir
Feb 11, 2012·Annals of Physical and Rehabilitation Medicine·M de Sèze, E Cugy
Jan 17, 2014·Journal of Children's Orthopaedics·Romain DayerPierre Lascombes
Jun 1, 2014·The Spine Journal : Official Journal of the North American Spine Society·Suzan ChenEugene K Wai
Jun 26, 2014·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Mingyuan YangMing Li
Mar 26, 2015·International Orthopaedics·Aleksandra KulisDaniel Zarzycki
Apr 23, 2015·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Mingyuan YangMing Li
Dec 22, 2015·Molecular Biology Reports·Catarina Addobbati Jordão CavalcantiPaula Sandrin-Garcia
Jan 1, 2015·Nature Reviews. Disease Primers·Jack C ChengR Geoffrey Burwell
Aug 19, 2016·The Journal of Bone and Joint Surgery. American Volume·M Timothy HreskoUNKNOWN AAOS, SRS, and POSNA
Oct 26, 2016·International Journal of Rheumatic Diseases·Pingping ZhangJieruo Gu
Dec 6, 2016·Frontiers in Surgery·Nikolay L MartirosyanNicholas Theodore
Dec 10, 2016·Scoliosis and Spinal Disorders·A GrauersP Gerdhem
Dec 21, 2016·Asian Spine Journal·Hans-Rudolf WeissKathryn Moramarco
Jan 10, 2017·Journal of the American College of Nutrition·Michal KarpińskiSidney J Stohs
Feb 9, 2017·Trends in Genetics : TIG·Curtis W Boswell, Brian Ciruna
Apr 8, 2017·Journal of Neuroimmunology·Víctor Hugo Bermúdez-MoralesCarlos Hernández-Girón

❮ Previous
Next ❯

Citations

Apr 13, 2019·Molecular Biology Reports·Gulten TuncelMahmut Cerkez Ergoren
Jan 24, 2020·Chinese Medical Journal·Yue PengQian-Yu Zhuang
Dec 8, 2020·Revista española de cirugía ortopédica y traumatología·V ObertiJ Masquijo
Dec 31, 2020·International Journal of Inflammation·Janisleya Silva Ferreira NevesAna Maria Sell
Jul 11, 2021·Central European Journal of Public Health·Emine KandemişMahmut Çerkez Ergören

❮ Previous
Next ❯

Methods Mentioned

BETA
neutron capture
genotyping

Software Mentioned

Stata
Power and Precision

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.