PMID: 11898916Mar 20, 2002Paper

Association of vitamin D receptor gene BsmI polymorphisms in Chinese patients with systemic lupus erythematosus

Lupus
C M HuangF J Tsai

Abstract

The purpose of this study was to evaluate whether vitamin D receptor (VDR) genes BsmI polymorphisms were markers for susceptibility to or severity of systemic lupus erythematosus (SLE) in Chinese patients in Taiwan. The study included 47 Chinese patients with SLE. In addition, 90 unrelated, healthy individuals living in central Taiwan served as control subjects. Each polymorphism was detected as a result of polymerase chain reaction (PCR)-based restriction analysis. A PCR product length was determined to be 580bp (BB) whereas two fragments of 405 and 175bp were determined to be excisable lengths (bb) by BsmI endonuclease. The relationship between Bsm polymorphisms and clinical manifestations of SLE was evaluated. We found that BB was significantly more common and bb less common in SLE than in control group (chi2 = 54.2, P < 0.0001). In addition, the frequency of B allele was also significantly more common in patients with SLE than in the healthy control subjects (chi2 = 38.7, P < 0.0001), giving an odds ratio of 7.14 (95% confidence interval 3.53-14.4). In the SLE patients, we did not detect any associations of VDR genotype with the clinical, laboratory profiles, or lupus nephritis (chi2 = 2.34, P = 0.3). This study indicated a...Continue Reading

References

Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·N A MorrisonJ A Eisman
Mar 1, 1991·The Journal of Clinical Investigation·J M Lemire, D C Archer
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A R BakerB W O'Malley
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
Jun 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J C FleetB Dawson-Hughes
Jan 20, 1994·Nature·N A MorrisonJ A Eisman
May 3, 1996·Cell·B L Kotzin
Dec 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C GrossD Feldman
Dec 1, 1996·Current Opinion in Immunology·T J Vyse, B L Kotzin
Jul 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S S HarrisD Feldman

❮ Previous
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Citations

Jun 14, 2012·Clinical Rheumatology·Odirlei André MonticieloRicardo Machado Xavier
Oct 16, 2012·Molecular Biology Reports·Adrianna MostowskaPaweł P Jagodziński
Jun 23, 2009·Clinical Reviews in Allergy & Immunology·Yinon ShapiraYehuda Shoenfeld
Jan 7, 2011·Clinical Reviews in Allergy & Immunology·Aaron LernerYehuda Shoenfeld
Jan 30, 2013·Clinical Reviews in Allergy & Immunology·Chen-Yen YangM Eric Gershwin
Jun 8, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jorge Rojas-RiveraJesús Egido
Aug 14, 2008·Current Opinion in Rheumatology·Diane Kamen, Cynthia Aranow
Jun 15, 2007·Annals of the Rheumatic Diseases·Yoav ArnsonYehuda Shoenfeld
Mar 2, 2006·Arthritis Research & Therapy·Wilaiporn SakulpipatsinSuchela Janwityanujit
Feb 6, 2013·PloS One·Rajalingham Sakthiswary, Azman Ali Raymond
Jun 20, 2003·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Vasileios Kyttaris, George Tsokos
Jul 18, 2012·Clinical Rheumatology·Khanh vinh quốc Luong, Lan Thi Hoàng Nguyễn
Jul 30, 2008·Current Rheumatology Reports·Diane L Kamen, Cynthia Aranow
Jun 1, 2005·Rheumatic Diseases Clinics of North America·Andrea L SestakJohn B Harley
Feb 16, 2008·The American Journal of the Medical Sciences·Amitha ThudiNancy J Olsen
Jan 3, 2012·La Revue de médecine interne·Y SchoindreN Costedoat-Chalumeau
Aug 30, 2011·Best Practice & Research. Clinical Endocrinology & Metabolism·Tom L Van BelleChantal Mathieu
Mar 6, 2007·Seminars in Nephrology·Laurence Morel
Apr 24, 2004·Clinical Endocrinology·J E CollinsS C L Gough
Nov 15, 2013·Journal of Gastroenterology and Hepatology·Yuan-jun LiDai-ming Fan
Mar 28, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jose M Valdivielso, Elvira Fernandez
Jun 18, 2014·Journal of Autoimmunity·Sonia Berrih-Aknin
Nov 26, 2014·Scandinavian Journal of Rheumatology·S KolahiE Sakhinia
May 24, 2014·Journal of Receptor and Signal Transduction Research·Tian-Biao ZhouNing Su
Feb 17, 2015·BioMed Research International·Mehrnaz Narooie-NejadAli Moghtaderi
Jun 11, 2016·Annals of the Rheumatic Diseases·Kendra A YoungJill M Norris
May 18, 2007·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Gerard E Mullin, Adrian Dobs
Jan 27, 2006·Journal of Applied Animal Welfare Science : JAAWS·Leena AnilJohn Deen
Apr 5, 2017·Scientific Reports·Julia GroeningMandyam V Srinivasan
Feb 1, 2005·European Journal of Epidemiology·Barbara AngelFrancisco Pérez-Bravo

❮ Previous
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