Association of vitamin D receptor gene polymorphisms in Chinese patients with generalized aggressive periodontitis

Journal of Periodontal Research
S LiJ Q Zeng

Abstract

The clinical features suggest that genetic factors may have a strong influence on susceptibility to aggressive periodontitis. The aim of this study was to investigate the association of vitamin D receptor gene polymorphisms with generalized aggressive periodontitis in Chinese patients. A restriction fragment length polymorphism (RFLP) for 10,438,141 C to T (rs1544410, BsmI), 10,382,063 A to G (rs731236, TaqI), 10,382,143 C to A (rs7975232, ApaI) and 10,416,201 A to G (rs2228570, FokI) of vitamin D receptor gene was analysed by polymerase chain reaction, followed by digestion with restriction enzymes and gel electrophoresis. The genotypes of 51 generalized aggressive periodontitis patients and 53 periodontally healthy control subjects were analysed. The genotypic and allelic frequencies of each polymorphism site for the patients and control subjects were compared. The distribution of vitamin D receptor FokI genotypes and alleles between the two groups was significantly different (p = 0.043 and p = 0.012, respectively). The F allele seemed to increase the susceptibility of aggressive periodontitis (odds ratio = 2.02, 95% confidence interval = 1.16-3.50) in Chinese patients. There was no significant difference in the genotype dist...Continue Reading

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Citations

Mar 23, 2011·Infection and Immunity·Laura McMahonGill Diamond
Jul 1, 2009·Journal of Periodontology·Kaining LiuRuifang Lu
Dec 29, 2010·Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research·R VijayalakshmiPamela Emmadi
Oct 26, 2013·Climacteric : the Journal of the International Menopause Society·H ShenH Lu
Apr 20, 2011·Periodontology 2000·Jincai ZhangGang Luo
Apr 18, 2014·Periodontology 2000·Alexandre R Vieira, Jasim M Albandar
Sep 21, 2018·Genetic Testing and Molecular Biomarkers·Vaishnavi RatheeshDhayanand John Victor
Dec 18, 2013·Archives of Disease in Childhood·Song Mao, Songming Huang
Dec 3, 2011·Periodontology 2000·Marja L LaineBruno G Loos
Sep 30, 2016·Clinical and Experimental Dental Research·Anna Maria HeikkinenTimo Sorsa

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