Association of vitamin D supplementation with respiratory tract infection in infants.

Maternal & Child Nutrition
Miao HongLiping Hao

Abstract

Vitamin D deficiency has been reported to be associated with respiratory tract infection (RTI). However, evidence regarding the effects of vitamin D supplementation on susceptibility of infants to RTI is limited. In this prospective birth cohort study, we examined whether vitamin D supplementation reduced RTI risk in 2,244 infants completing the follow-up from birth to 6 months of age. The outcome endpoint was the first episode of paediatrician-diagnosed RTI or 6 months of age when no RTI event occurred. Infants receiving vitamin D supplements at a daily dose of 400-600 IU from birth to the outcome endpoint were defined as vitamin D supplementation and divided into four groups according to the average frequency of supplementation: 0, 1-2, 3-4, and 5-7 days/week. We evaluated the relationship between vitamin D supplementation and time to the first episode of RTI with Kaplan-Meier plots. The associations of vitamin D supplementation with infant RTI, lower RTI (LRTI), and RTI-related hospitalization were assessed using modified Poisson regression. The median time to first RTI episode was 60 days after birth (95% CI [60, 90]) for infants without supplementation and longer than 6 months of age for infants with supplementation (p < ....Continue Reading

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Citations

Jul 23, 2020·Frontiers in Pediatrics·Gavriela FeketeaMihnea Tudor Zdrenghea
Apr 17, 2020·American Journal of Physiology. Endocrinology and Metabolism·Hrvoje Jakovac
Sep 12, 2020·Irish Journal of Psychological Medicine·Dylan Viani-WalshJohn Lally
Apr 6, 2021·Journal of Diabetes and Metabolic Disorders·Aysha Habib KhanRehana Rehman
Oct 15, 2021·The Tohoku Journal of Experimental Medicine·Siamak AfaghiNasser Malekpour Alamdari

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