Association studies on 11 published colorectal cancer risk loci.

British Journal of Cancer
Susanna von HolstAnnika Lindblom

Abstract

Recently, several genome-wide association studies (GWAS) have independently found numerous loci at which common single-nucleotide polymorphisms (SNPs) modestly influence the risk of developing colorectal cancer. The aim of this study was to test 11 loci, reported to be associated with an increased or decreased risk of colorectal cancer: 8q23.3 (rs16892766), 8q24.21 (rs6983267), 9p24 (rs719725), 10p14 (rs10795668), 11q23.1 (rs3802842), 14q22.2 (rs4444235), 15q13.3 (rs4779584), 16q22.1 (rs9929218), 18q21.1 (rs4939827), 19q13.1 (rs10411210) and 20p12.3 (rs961253), in a Swedish-based cohort. The cohort was composed of 1786 cases and 1749 controls that were genotyped and analysed statistically. Genotype-phenotype analysis, for all 11 SNPs and sex, age of onset, family history of CRC and tumour location, was performed. Of eleven loci, 5 showed statistically significant odds ratios similar to previously published findings: 8q23.3, 8q24.21, 10p14, 15q13.3 and 18q21.1. The remaining loci 11q23.1, 16q22.1, 19q13.1 and 20p12.3 showed weak trends but somehow similar to what was previously published. The loci 9p24 and 14q22.2 could not be confirmed. We show a higher number of risk alleles in affected individuals compared to controls. Four s...Continue Reading

References

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Citations

Nov 13, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jing HeChristopher A Haiman
Apr 13, 2011·World Journal of Gastroenterology : WJG·Yi GuoHeng-Jun Gao
Jan 30, 2013·Chinese Journal of Cancer Research = Chung-kuo Yen Cheng Yen Chiu·Fen-Xia LiMing Li
Dec 14, 2011·American Journal of Epidemiology·Steven J LubbeRichard S Houlston
Jan 12, 2012·Carcinogenesis·María Dolores GiráldezUNKNOWN Gastrointestinal Oncology Group of the Spanish Gastroenterological Association
Sep 9, 2016·Frontiers in Oncology·Mev Dominguez-ValentinCarlos A Vaccaro
Aug 30, 2017·Journal of Cancer Research and Clinical Oncology·Makiko AbeKeitaro Matsuo
Jul 22, 2014·Journal of Surgical Oncology·Yuan-Tzu LanShih-Ching Chang
Aug 1, 2019·Journal of Cellular Biochemistry·Chin-Sheng HungPo-Li Wei
Dec 5, 2015·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Satoyo HosonoKeitaro Matsuo
Jul 5, 2011·Journal of Gastroenterology and Hepatology·Monir Sadat HaerianBatoul Sadat Haerian
Jan 1, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yin-Ping WangZhi-Yong Shen
Dec 1, 2018·Mediators of Inflammation·Amal Ahmed Abd El-FattahAmal Mohamed Kamal
Dec 16, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Aung Ko WinMark A Jenkins
Jul 6, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Elizabeth D KantorEmily White

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Methods Mentioned

BETA
Genotyping
Assay
PCR

Software Mentioned

Statistica
SeqScape

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