PMID: 11924728Apr 2, 2002Paper

Association study between a novel single nucleotide polymorphism of the promoter region of the prostacyclin synthase gene and essential hypertension

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Tomohiro NakayamaShinichiro Kokubun

Abstract

The purpose of this study was to investigate whether an association exists between the promoter region of the prostacyclin synthase gene and essential hypertension (EH). Using the polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) method, we discovered a novel single nucleotide polymorphism (SNP), T-192G, in the 5'-flanking region. We performed an association study using the SNP in 200 patients and 200 controls. The allele frequency distribution in the two groups was not significantly different. Thus, this SNP in the PGIS gene is not associated with EH.

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Citations

Jul 11, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Xiaoyan WangPedro A Jose
Oct 10, 2002·Biochemical and Biophysical Research Communications·Tomohiro NakayamaJohn A Oates
Jul 24, 2007·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Mikano SatoShinichiro Kokubun
May 4, 2004·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Tomohiro NakayamaShinichiro Kokubun
Jul 24, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Tomohiro NakayamaShinichiro Kokubun
Jul 17, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Buaijiaer HasimuYukio Ozawa
Aug 20, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Zhihong WuTetsuro Miki
Aug 20, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Tomohiro NakayamaShinichiro Kokubun
Mar 31, 2005·American Journal of Hypertension·Morihiko SanoShinichiro Kokubun
Jan 17, 2009·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis· Xiang Xie Fen Liu
Sep 14, 2004·Journal of Human Hypertension·M O M Tanira, K A Al Balushi

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