Association study between C7673T polymorphism in apolipoprotein B gene and cerebral infarction with family history in a Chinese population

Neurology India
Le ZhangXiaoping Du

Abstract

Apolipoprotein B (ApoB) levels have been shown to be associate with risk of ischemic stroke. The apolipoprotein B gene (APOB) polymorphisms may influence levels of ApoB and risk of ischemic stroke, but whether they are associated with risk of ischemic cerebral infarction (CI) with family history (CIFH) or not is unknown. To investigate the possible association of the polymorphism of APOB C7673T with CIFH in Han Chinese from Changsha. The study population included 47 patients with CIFH and 83 patients with cerebral infarction with no family history (CINFH). Control population included 100 healthy subjects with no history of ischemic stroke matched for age, sex, and ethnic background. The APOB C7673T polymorphism was analyzed by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Plasma lipids levels were also examined by standard enzymatic methods and enzyme-linked immunosorbent assay (ELISA). The statistical analysis was done using SPSS 14.0 software package. A P value < 0.05 was taken as significant. This study showed an association between the APOB C7673T polymorphism and CI, especially CIFH in Han Chinese from Changsha. The T alleles frequency of the C7673T polymorphism was significantly higher...Continue Reading

Citations

Aug 20, 2011·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Liu HuiXu Xiaoting
Mar 6, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Yi ZengXiaoPing Du
Dec 1, 2015·Journal, Genetic Engineering & Biotechnology·Nayera E HassanMaged Mostafa Mahmoud

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.