Association study between IL-17A and IL-17F gene polymorphism and myasthenia gravis in Chinese patients

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Yao-Xian YueHai-Feng Li

Abstract

Alleles of IL-17A and IL-17F genes were reported to be associated with many inflammatory and autoimmune disorders in Asian patients. Serum level and mRNA of IL-17A in peripheral blood mononuclear cells were reported to be significantly higher in MG patients than in healthy controls. In experimental autoimmune myasthenia gravis (EAMG) animals, IL-17 may have effects on the severity of MG. This study investigated the association between four SNPs of IL-17A and IL-17F gene (rs8193036, rs2275913 and rs3748067 in IL-17A; rs763780 in IL-17F) and MG in Chinese patients. The allele frequencies were compared between 480 MG patients and 487 healthy controls, between each MG subgroup and the control group, and between each pairs of MG subgroups. Subgroups were specified by clinical features (onset age, gender, thymoma, AChRAb and muscle involvement at onset) and maximal severity during the follow-up. No associations were found between the four SNPs of IL-17A and IL-17F gene and MG in Chinese patients.

References

Apr 13, 1999·Archives of Neurology·G O SkeieN E Gilhus
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Dec 7, 2007·Muscle & Nerve·David GrobMurali Pagala
Jun 24, 2008·Annals of the New York Academy of Sciences·Matthieu GiraudHenri-Jean Garchon
Jun 24, 2008·Annals of the New York Academy of Sciences·Johan A Aarli
Aug 23, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G O Skeie, F Romi
Jan 10, 2009·Annual Review of Immunology·Thomas KornVijay K Kuchroo
Apr 21, 2009·Lancet Neurology·Matthew N Meriggioli, Donald B Sanders
Apr 13, 2010·Autoimmunity·A MarxP Ströbel
Feb 26, 2011·Immunity·Yoichiro IwakuraSusumu Nakae
Jun 19, 2012·Journal of Thrombosis and Haemostasis : JTH·X ChenX Wang
Sep 8, 2012·Clinical and Experimental Medicine·Ranji HayashiTomiyasu Arisawa

❮ Previous
Next ❯

Citations

Jul 26, 2018·Frontiers in Neurology·Ping JiangXu Zhang
Feb 27, 2021·Frontiers in Neurology·Ji-Lan HanHai-Feng Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Journal of Gastrointestinal and Liver Diseases : JGLD
Ranji HayashiTomiyasu Arisawa
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Nan WangXianli He
© 2021 Meta ULC. All rights reserved