Association study between obsessive-compulsive disorder and serotonergic candidate genes

Progress in Neuro-psychopharmacology & Biological Psychiatry
Pilar A SaizJulio Bobes

Abstract

To date, research examining the relationship between serotonergic genes and obsessive-compulsive disorder (OCD) has yielded conflicting results. The purpose of this study is to investigate the association between four serotonergic polymorphisms (STin2 VNTR and 5-HTTLPR of the SLC6A4 gene, and A-1438G (rs6311) and T102C (rs6313) of the HTR2A gene) and OCD. 99 OCD patients, 456 non-OCD psychiatric patients, and 420 healthy controls from a homogeneous Spanish Caucasian population were genotyped using standard methods. All groups showed Hardy-Weinberg equilibrium for the analyzed genetic variability. A-1438G and T102C polymorphisms were in complete linkage disequilibrium. OCD patients showed an excess of STin2.12 carriers (12/12, 12/10, and 12/9 genotypes) compared with healthy controls (chi(2) (1)=7.21, corrected p=0.021; OR=3.38, 95% CI=1.32-8.62) and non-OCD psychiatric patients (chi(2) (1)=6.70, corrected p=0.030; OR=3.24, 95% CI=1.27-8.26). However, no differences were found between non-OCD patients and healthy controls (chi(2) (1)=0.05, corrected p>1; OR=1.04, 95% CI=0.72-1.51). No significant differences were found with respect to A-1438G and 5-HTTLPR polymorphisms. Our data provide supporting evidence of an association betw...Continue Reading

References

Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Sep 1, 1980·The British Journal of Psychiatry : the Journal of Mental Science·P McGuffin, D Mawson
Jun 16, 1999·Progress in Neuro-psychopharmacology & Biological Psychiatry·K OharaK Ohara
Apr 18, 2000·Archives of General Psychiatry·G NestadtR Hoehn-Saric
May 4, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·A FrischR Weizman
May 23, 2000·Lancet·M J ArranzR W Kerwin
May 10, 2001·Schizophrenia Research·C VirgosE Vilella
Jun 22, 2001·European Psychiatry : the Journal of the Association of European Psychiatrists·J BobesM Bousoño
Oct 17, 2001·The International Journal of Neuropsychopharmacology·B CamarenaH Nicolini
Mar 29, 2002·American Journal of Medical Genetics·Maria Cristina CavalliniLaura Bellodi
Jun 26, 2002·The Pharmacogenomics Journal·D Di BellaL Bellodi
Mar 26, 2003·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Sîan M J HemmingsDan J Stein
Jul 19, 2003·Molecular Pharmacology·Fusun KilicGary Rudnick
Jan 27, 2004·Schizophrenia Research·Hamid Mostafavi AbdolmalekyMing T Tsuang
Mar 30, 2004·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·I MataR W Kerwin
Jun 19, 2004·European Archives of Psychiatry and Clinical Neuroscience·Jules AngstWulf Rössler
May 24, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Enrique Baca-GarcíaJose de Leon
Jan 31, 2006·Journal of Affective Disorders·Damiaan DenysHerman G M Westenberg
Apr 28, 2006·American Journal of Human Genetics·Xian-Zhang HuDavid Goldman
Dec 19, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Enrique Baca-GarciaJeronimo Saiz-Ruiz

❮ Previous
Next ❯

Citations

Sep 12, 2014·Current Psychiatry Reports·Brian ReedMary Jeanne Kreek
Feb 20, 2016·Neuroscience and Biobehavioral Reviews·Susana Aznar, Mona El-Sayed Hervig
Apr 11, 2015·Asia-Pacific Psychiatry : Official Journal of the Pacific Rim College of Psychiatrists·Longqiang XuShiguo Liu
Feb 16, 2013·Expert Opinion on Investigational Drugs·Tiago A MestreSusan H Fox
Feb 2, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Gabriella Francesca Mattina, Meir Steiner
Aug 25, 2009·European Psychiatry : the Journal of the Association of European Psychiatrists·L MaurexR Leopardi
Mar 31, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Pilar A SaizJulio Bobes
Dec 30, 2008·Drug and Alcohol Dependence·Evelise Regina PolinaClaiton Henrique Dotto Bau
Sep 3, 2010·Headache·Salvatore TerrazzinoArmando A Genazzani
Mar 3, 2010·Human Psychopharmacology·Francesco PivaGiovanni Principato
Jan 15, 2011·The International Journal of Neuropsychopharmacology·Swen HesseOsama Sabri
Aug 1, 2020·Journal of Affective Disorders·Gabriella Francesca MattinaMeir Steiner

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Related Papers

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
Michael H BlochJames F Leckman
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
J R WendlandD L Murphy
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Werner ZitterlKenneth Thau
© 2021 Meta ULC. All rights reserved