Association study of 15 novel single-nucleotide polymorphisms of the T-bet locus among Finnish asthma families

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
E YlikoskiR Lahesmaa

Abstract

T-box expressed in T cells (T-bet) is a transcription factor regulating the commitment of T helper (Th) cells by driving the cells into the Th1 direction. Abnormal Th1/Th2 balance may lead to complex disorders like asthma or autoimmune diseases. Recent studies have suggested that T-bet might be a candidate gene for asthma. This led us to screen 23 Finnish individuals for single-nucleotide polymorphisms (SNPs) in the T-bet locus and study the association between the SNPs and high serum IgE level and asthma. We screened all six exons, adjacent intronic areas and 2 kb of the 5'-flanking region from 23 individuals utilizing WAVE trade mark technology. To explore whether T-bet is associated in serum IgE regulation or asthma we genotyped the SNPs in a Finnish asthmatic founder population. The association analyses were made using haplotype pattern mining. Fifteen novel SNPs were found in the T-bet gene. Within the Finnish asthmatic founder population, there was no association between T-bet SNPs and high serum IgE level or asthma. The genetic variability in the T-bet gene does not play a role in the pathogenesis of human asthma. Our results provide a novel panel of SNPs in T-bet and will help determine whether the SNPs have a functiona...Continue Reading

References

Jun 23, 1998·American Journal of Human Genetics·J R O'Connell, D E Weeks
Jan 23, 1999·Nature Genetics·A Chakravarti
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·L X ShenV P Stanton
Jan 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·R G NickelS K Huang
Sep 27, 2000·Human Molecular Genetics·W O Cookson, M F Moffatt
Nov 9, 2000·American Journal of Respiratory and Critical Care Medicine·M H DizierF Demenais
Mar 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A W GibsonR P Kimberly
Nov 10, 2001·Annual Review of Genomics and Human Genetics·J Kere
Dec 26, 2001·Proceedings of the National Academy of Sciences of the United States of America·A A LighvaniJ J O'Shea
May 8, 2002·The Journal of Experimental Medicine·M F NeurathR S Blumberg
May 15, 2002·Nature Immunology·Maryam AfkarianKenneth M Murphy
Jul 12, 2002·Nature·Paul Van EerdeweghTim P Keith
Jul 18, 2002·Allergy·A HaagerupT A Kruse

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Citations

Apr 5, 2005·Human Genetics·Mitsuteru AkahoshiTaro Shirakawa
Jul 21, 2004·Nucleic Acids Research·Jonne VaarnoAleksi E Soini
Sep 24, 2005·American Journal of Respiratory and Critical Care Medicine·Benjamin A RabyScott T Weiss
Mar 17, 2009·Experimental & Molecular Medicine·Soo Cheon ChaeHun Taeg Chung
May 20, 2008·Annals of Medicine·Kirsi J RautajokiRiitta Lahesmaa
Apr 14, 2009·The Journal of Allergy and Clinical Immunology·Kathrin SuttnerMichael Kabesch
Nov 29, 2008·The Journal of Allergy and Clinical Immunology·Kathrin SuttnerMichael Kabesch
Oct 24, 2007·The Journal of Allergy and Clinical Immunology·Monica Cheng Munthe-KaasDag Undlien
Oct 11, 2013·Scientific Reports·Anton LopertMatjaž Fležar
May 29, 2009·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Song ChenGuohong Deng
Mar 12, 2015·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·D Y ZhuM Yue
Jan 8, 2005·The Journal of Allergy and Clinical Immunology·Maritta PykäläinenRiitta Lahesmaa
Jul 25, 2014·Journal of Human Genetics·Neeraj SharmaShally Awasthi

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