PMID: 11920846Mar 29, 2002Paper

Association study of a SNAP-25 microsatellite and attention deficit hyperactivity disorder

American Journal of Medical Genetics
J MillP J Asherson

Abstract

Several lines of evidence implicate synaptosomal-associated protein of 25 kDa (SNAP-25) in the etiology of attention deficit hyperactivity disorder (ADHD). Most notably, the coloboma mouse mutant, considered to be a good animal model of hyperactivity, has a deletion spanning this gene. Introducing a SNAP-25 transgene into these animals alleviates hyperlocomotion. We have identified a novel microsatellite repeat in SNAP-25 located between the 5'UTR and the first coding exon, and tested for association with ADHD. Case-control analyses suggest there may be a role of this polymorphism in ADHD, with one allele over-represented in controls and another over-represented in probands. Within-family tests of linkage and association confirmed these findings. Further work is needed to ascertain the role of SNAP-25 in ADHD and assess the functional significance of this polymorphism.

References

Dec 1, 1996·Methods : a Companion to Methods in Enzymology·E J Hess
Dec 24, 1998·Nucleic Acids Research·G Benson

❮ Previous
Next ❯

Citations

Sep 4, 2003·Mental Retardation and Developmental Disabilities Research Reviews·John A FossellaMichael I Posner
Mar 25, 2004·Current Psychiatry Reports·Lindsey Kent
Nov 19, 2003·European Journal of Pharmacology·David A Keays, Patrick M Nolan
May 22, 2003·Pharmacology, Biochemistry, and Behavior·Michelle D Jones, Ellen J Hess
May 18, 2007·Psychological Medicine·Anita ThaparMichael C O'Donovan
Dec 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Davide PozziMichela Matteoli
Jun 5, 2008·Journal of Pediatric Psychology·Deeann WallisMaximilian Muenke
Jan 17, 2004·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Maria Teresa AcostaMaximilian Muenke
Jan 21, 2004·The Australian and New Zealand Journal of Psychiatry·Max YehWayne D Hall
Dec 31, 2009·Genes, Brain, and Behavior·N IlottP Asherson
Jul 19, 2005·Behavioral and Brain Functions : BBF·Vivienne A RussellEspen Borgå Johansen
May 28, 2014·Psychiatry Research·Zhao LiJing Wang
Nov 22, 2005·Expert Opinion on Drug Delivery·Kennerly S PatrickJohn S Markowitz
Feb 10, 2016·Journal of Neural Transmission·Renata Basso CupertinoNina Roth Mota
Jul 6, 2010·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Hongyu ZhangHong Chang
Feb 18, 2010·The Psychiatric Clinics of North America·Stephen V Faraone, Eric Mick
Feb 26, 2008·Child and Adolescent Psychiatric Clinics of North America·Eric Mick, Stephen V Faraone
Nov 6, 2007·Journal of Neuroscience Methods·Vivienne Ann Russell
Feb 24, 2007·Neuroscience and Biobehavioral Reviews·Michael A van der Kooij, Jeffrey C Glennon
Feb 13, 2007·Neurobiology of Disease·Xueliang Fan, Ellen J Hess
Feb 6, 2007·Journal of Neuroscience Methods·Vivienne Ann Russell
Oct 27, 2006·Neurobiology of Disease·Kristy J BrunoEllen J Hess
Feb 22, 2005·Developmental Science·Jim StevensonErik Willcutt
Feb 18, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Aaron J BobbJudith L Rapoport
Jan 16, 2008·Journal of Neurochemistry·Fang CaiWeihong Song
Jan 24, 2009·Annals of the New York Academy of Sciences·Irene CorradiniMichela Matteoli
Jun 14, 2005·Biological Psychiatry·Stephen V FaraonePamela Sklar
Oct 7, 2015·Frontiers in Psychiatry·Viviane SchuchMauro Muszkat
Sep 4, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Cristina Sánchez-MoraMarta Ribasés
Mar 4, 2006·Clinical Psychology Review·Irwin D Waldman, Ian R Gizer
Nov 3, 2016·The International Journal of Neuroscience·Aneeqa Noor, Saadia Zahid
Mar 10, 2004·Molecular Psychiatry·J MillP Asherson
Jan 6, 2011·Current Protocols in Neuroscience·Vivienne Ann Russell
Aug 9, 2017·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Eunjoo KimKeun-Ah Cheon
Feb 9, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Aaron J BobbJudith L Rapoport
Apr 7, 2007·Psychiatric Genetics·Rohit MakkarCathy L Barr
Feb 19, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Xiaohui XuPhilip Asherson
Aug 6, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·K J BrookesP Asherson
Aug 6, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Xiaohui XuPhilip Asherson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.