Association study of angiotensin converting enzyme gene polymorphism with elderly diabetic hypertension and lipids levels

Lipids in Health and Disease
Yun-Fei ZhouHui-Lan Luo

Abstract

To investigate the relationship between angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and diabetic essential hypertension in elderly population. Polymerase chain reaction (PCR) technique was used in 260 elderly normal control patients, 205 elderly hypertensive patients and 138 elderly diabetic hypertensive patients to detect the I/D polymorphism in ACE gene. DD genotype frequency (0.352) and D allele frequency (0.543) in elderly hypertensive patients were higher than those in the normal control patients. DD genotype (0.421) and D allele frequency (0.579) in elderly diabetic hypertensive patients were significantly higher than those in the control patients (0.133 and 0.250). The differences of DD genotype and D allele frequency between the elderly hypertensive patients and the elderly diabetic hypertensive patients were not significant (P > 0.05). ACE gene deletion is a risk factor for hypertension but is not a risk factor for diabetes in elderly population.

References

Sep 14, 2002·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Jean-Jacques MouradMichel E Safar
May 10, 2007·Postgraduate Medical Journal·Imen ArfaSonia Abdelhak
Jul 27, 2007·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Puneetpal SinghTaranpal Kaur
Apr 12, 2008·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Imen ArfaSonia Abdelhak
Mar 7, 2012·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Donghao ZhouShengxiang Wang
Nov 1, 2012·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Chun-Hsiang WangEugene Lin

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Citations

Jan 22, 2015·Meta Gene·Murali VijayanBalakrishnan Karuppiah
Jun 16, 2015·Frontiers in Endocrinology·Ini-Isabée WitzelHabiba Alsafar
Jan 31, 2018·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Yong-Chao QiaoHai-Lu Zhao
May 15, 2019·Diabetes/metabolism Research and Reviews·Dimitra KallinikouKyriaki Karavanaki

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Methods Mentioned

BETA
Genotyping
PCR

Software Mentioned

SPSS

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