Association study of MIA3 rs17465637 polymorphism with cardiovascular disease in rheumatoid arthritis patients

DNA and Cell Biology
M García-BermúdezMiguel A González-Gay

Abstract

Rheumatoid arthritis (RA) is a complex polygenic inflammatory disease associated with accelerated atherosclerosis. Melanoma inhibitor protein 3 (MIA3) is required for the export of collagen VlI (COL7A1) from the endoplasmic reticulum and it appears to be a tumor suppressor of malignant melanoma. Genome-wide association studies have described an association between MIA3 rs17465637 A/C polymorphisms and coronary artery disease and myocardial infarction. Because of that, we assessed the MIA3 rs17465637 polymorphism in 1505 RA Spanish patients stratified according to the presence/absence of cardiovascular (CV) disease. Also, a subgroup of patients without CV events was assessed for the presence of subclinical atherosclerosis using carotid ultrasound to establish carotid intima-media wall thickness and carotid plaques and brachial ultrasonography to determine the presence of endothelial dysfunction by flow-mediated endothelium-dependent and independent vasodilatation. MIA3 rs17465637 allele A showed a trend for association with the presence of carotid plaques (odds ratio 1.56, 95% confidence interval [0.96-2.51]; p=0.07). However, apart from an association of the MIA3 rs17465637 A allele with the risk of CV events in RA patients wit...Continue Reading

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Citations

Oct 2, 2012·Mediators of Inflammation·Lorenzo CavagnaRoberto Caporali
May 4, 2016·The Journal of Cell Biology·António J M SantosVivek Malhotra
Dec 20, 2017·Current Opinion in Rheumatology·György NagyEdit I Buzás
Jul 23, 2021·Biochimica Et Biophysica Acta. Biomembranes·Ishier RaoteVivek Malhotra

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Methods Mentioned

BETA
genotyping

Software Mentioned

STATA
StatsDirect

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