Association study of the adrenergic receptors and childhood-onset mood disorders in Hungarian families

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
I BurcescuInternational Consortium for Childhood-Onset Mood Disorders

Abstract

The adrenergic system has been implicated in the etiology of depression based on a number of lines of evidence, particularly, the mechanism of some classes of antidepressants which increase the synaptic levels of norepinephrine. Further, several genome scans for mood disorders, both unipolar and bipolar, have indicated linkage to the chromosomal regions of 5q23-q33.3, 8p12-p11.2, 4p16, and 10q24-q26, the location of the adrenergic receptors alpha1B (ADRA1B), beta3 (ADRB3), alpha2C (ADRA2C), alpha2A (ADRA2A), and beta1 (ADRB1). In this manuscript, we report on the relationship of the adrenergic receptors and depression using a family based association approach and 189 families (223 affected children) with childhood-onset mood disorder (COMD) collected in Hungary. We found no significant evidence for an association with any of the 24 markers, in total, tested across these genes using single marker analysis or haplotypes of markers across these genes. The results in the present sample indicate that these nine genes are unlikely to be major susceptibility genes contributing to COMD.

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Citations

Jun 13, 2012·Psychological Medicine·S Cohen-WoodsP McGuffin
Nov 1, 2013·Dermatology Research and Practice·Giuseppe StincoPasquale Patrone
Oct 14, 2009·The European Journal of Neuroscience·Emma L DempsterUNKNOWN International Consortium for Childhood-Onset Mood Disorders
Nov 28, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Karen WiggCathy L Barr
May 29, 2009·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Emma L DempsterUNKNOWN International Consortium for Childhood-Onset Mood Disorders
Mar 24, 2016·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Guadalupe RiveroJ Javier Meana
Feb 16, 2017·Scientific Reports·Xiaobin ZhangMarie-Laure Ancelin
Oct 18, 2016·Clinical Psychological Science : a Journal of the Association for Psychological Science·Maria KovacsKrisztina Kapornai
Dec 14, 2007·Psychiatric Genetics·Yu FengUNKNOWN International Consortium for Childhood-Onset Mood Disorders
Aug 9, 2007·The Pharmacogenomics Journal·A SerrettiJ L Kennedy
May 26, 2017·The British Journal of Clinical Psychology·Ena BegovicJonathan Rottenberg
May 28, 2019·Journal of Affective Disorders·Gabriel R FriesJoao Quevedo

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