Association study of the CFH Y402H polymorphism with Alzheimer's disease.

Neurobiology of Aging
Isabelle Le FurJean-Charles Lambert

Abstract

Several reports indicated that Alzheimer's disease (AD) and age-related macular degeneration (AMD) may share similar genetic and pathological features. We postulated that the functional Y402H polymorphism within the CFH gene and unambiguously recognised as a major genetic determinant of AMD, may also be a risk factor of AD. We analysed the association of this polymorphism with the AD risk in both prospective and cross-sectional studies. We were not able to detect such an association whatever the studied population, suggesting that the CFH gene is not a genetic determinant of AD.

References

Oct 31, 2006·Brain : a Journal of Neurology·A HyeS Lovestone

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Citations

Aug 6, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Deng-Feng ZhangYong-Gang Yao
Mar 29, 2011·Progress in Retinal and Eye Research·Kyoko Ohno-Matsui
Oct 1, 2015·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Michael A WilliamsPeter Passmore
Jul 16, 2015·PloS One·Helene Bæk JuelMogens Holst Nissen
Aug 29, 2016·Journal of Alzheimer's Disease : JAD·Svetlana HakobyanBryan Paul Morgan
Dec 29, 2020·Frontiers in Immunology·Seppo Meri, Karita Haapasalo

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