Association study of the SLC25A12 gene and autism in Han Chinese in Taiwan

Progress in Neuro-psychopharmacology & Biological Psychiatry
Wei-Hsien ChienChia-Hsiang Chen

Abstract

Autism is a childhood-onset neurodevelopmental disorder with a strong genetic component in its etiology. Several studies reported that the solute carrier family 25 member A12 (SLC25A12) gene was associated with autism. This study aimed to replicate this finding in a Han Chinese sample from Taiwan using a population-based case-control approach. We genotyped two single nucleotide polymorphisms (SNPs, rs2056202 and rs2292813) of the SLC25A12 gene that were previously reported to be associated with autism in 465 patients (402 males and 63 females) and 450 control subjects (227 males and 223 females) from Taiwan. Differences in the genotype, allele, and haplotype frequencies between the two groups were compared. We found no differences in the allele, genotype, or haplotype frequencies of these two SNPs between patients and controls. Our data do not support that the SLC25A12 gene is associated with autism in our population. The discrepant results of other studies may come from the clinical heterogeneity of patients recruited for studies, or the genetic heterogeneity of autism in different populations.

References

Jun 24, 2003·Journal of the American Academy of Child and Adolescent Psychiatry·Ovsanna Tadevosyan-LeyferSusan E Folstein
Nov 1, 2003·Molecular Psychiatry·E BacchelliUNKNOWN International Molecular Genetic Study of Autism Consortium (IMGSAC)
Apr 2, 2004·The American Journal of Psychiatry·Nicolas RamozJoseph D Buxbaum
Jun 16, 2004·Molecular Psychiatry·J Veenstra-VanderWeele, E H Cook
Nov 16, 2004·Neuroscience Letters·Raquel RabionetMargaret A Pericak-Vance
Jun 3, 2005·The American Journal of Psychiatry·Suniti Chakrabarti, Eric Fombonne
Sep 27, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Jeremy M SilvermanLauren A Kryzak
Mar 19, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Nicolas RamozJoseph D Buxbaum
Apr 17, 2008·Nature Reviews. Genetics·Brett S Abrahams, Daniel H Geschwind
Apr 11, 2009·Autism Research : Official Journal of the International Society for Autism Research·Joni A TurunenTero Ylisaukko-Oja

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Citations

Jul 3, 2013·Molecular Autism·Wei-Hsien ChienChia-Hsiang Chen
Apr 1, 2014·Molecular Autism·Jaroslava DurdiakováBhismadev Chakrabarti
May 18, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Yi-Ling ChienWei-Hsien Chien
Nov 29, 2015·Neurologic Clinics·Samantha E Marin, Russell P Saneto
Apr 30, 2015·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Jun LiuKe Yu
Sep 19, 2012·Research in Developmental Disabilities·Winnie Yu-Pow LauMiao-Chun Chou
Jun 13, 2012·Brain Research Bulletin·Xiaohong LiW Ted Brown
Feb 11, 2015·Molecular Neurobiology·Yuta Aoki, Samuele Cortese
Jul 25, 2018·Molecular Diagnosis & Therapy·Shannon RoseRichard E Frye
Jun 21, 2017·Oxidative Medicine and Cellular Longevity·Keren K Griffiths, Richard J Levy

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