Association study of the Ubiquilin gene with Alzheimer's disease

Neurobiology of Disease
Faiza BensemainJean-Charles Lambert

Abstract

Recently, the ubiquilin 1 gene has been proposed as a major candidate gene for AD. Here, we have investigated the potential impact of the UBQ-8i polymorphism (rs12344615) within this gene on the risk of developing AD. No association of this polymorphism with the disease was observed in a large French case-control population. Furthermore, no relationship between this polymorphism and Abeta load or degree of neurofibrillary degeneration in the brains of 114 patients with AD was detected.

References

Jul 1, 2004·Annals of Human Genetics·M Ilyas Kamboh
Mar 5, 2005·The New England Journal of Medicine·Lars BertramRudolph E Tanzi
Jul 1, 2005·The New England Journal of Medicine·Michael A SliferMargaret A Pericak-Vance

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Citations

Nov 13, 2008·Archives of Neurology·Joseph H LeeUNKNOWN National Institute on Aging Late-Onset Alzheimer's Disease Family Study Group
Mar 29, 2008·Neuroscience Bulletin·Xiao-Ping Wang, Hong-Liu Ding
Aug 20, 2011·The Journal of Biological Chemistry·Emily S StierenDarren Boehning
Apr 17, 2008·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Thomas D Bird
Mar 29, 2014·BMC Evolutionary Biology·Ignacio Marín
Jul 11, 2014·The International Journal of Neuroscience·Zhen YueFengyi Zhu
Jan 31, 2013·Prion·Amina El AyadiDarren Boehning
Mar 15, 2008·Dementia and Geriatric Cognitive Disorders·Maciej P GolanMaria Barcikowska
Apr 23, 2013·Expert Opinion on Therapeutic Targets·Mari TakaloMikko Hiltunen
Nov 13, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Tianpeng Zhang, Yingying Jia
Jan 16, 2010·Biochemical Society Transactions·Annakaisa HaapasaloMikko Hiltunen
Oct 20, 2007·Human Molecular Genetics·Atish GangulyMing Guo
Feb 27, 2021·Biochemical Society Transactions·Heather A Baker, Jonathan P Bernardini
Jun 6, 2009·Ageing Research Reviews·Davide SeripaAlberto Pilotto

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