Association study with 33 single-nucleotide polymorphisms in 11 candidate genes for hypertension in Chinese

Hypertension
Dongfeng GuBoqin Qiang

Abstract

Essential hypertension is considered to be a typical complex disease with multifactorial etiology, which leads to inconsistent findings in genetic studies. One possibility of failure to replicate some single-locus results is that the underlying genetics of hypertension are not only based on multiple genes with minor effects but also on gene-gene interactions. To test this hypothesis, a case-control study was constructed in Chinese subjects, detecting both single locus and multilocus effects. Eleven candidate genes were selected from biochemical pathways that have been implicated in the development and progression of hypertension, and 33 polymorphisms were evaluated in 503 hypertension patients and 490 age- and gender-matched controls. Single-locus associations, using traditional logistic regression analyses, and multilocus associations, using classification and regression trees and multivariate adaptive regression splines, were both explored in this study. Final models were selected using either Bonferroni correction or cross-validation. Three polymorphisms, TH*rs2070762, ADRB2*Q27E, and GRK4*A486V, were found to be independently associated with essential hypertension in Chinese subjects. In addition to these individual predict...Continue Reading

References

Sep 1, 1995·Statistical Methods in Medical Research·J H Friedman, C B Roosen
Nov 10, 1995·International Journal of Cardiology·X WuD Fan
Feb 14, 1998·The Journal of Biological Chemistry·H E Hamm
May 10, 2000·American Journal of Human Genetics·S A BacanuK Roeder
Jun 8, 2000·Bioinformatics·G R Abecasis, W O Cookson
Dec 7, 2000·Genetic Epidemiology·H Zhang, G Bonney
Feb 24, 2001·Current Opinion in Nephrology and Hypertension·D S TimberlakeR J Parmer
Apr 21, 2001·Biometrics·B Devlin, K Roeder
Aug 11, 2001·Science·F H WilsonR P Lifton
Jan 16, 2002·American Journal of Human Genetics·Daniel J SchaidGregory A Poland
Jan 16, 2002·American Journal of Human Genetics·Robert CulverhouseTheodore Reich
Mar 21, 2002·Clinical and Experimental Pharmacology & Physiology·M EslerG Lambert
Mar 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Robin A FelderPedro A Jose
Jul 11, 2002·Annals of Medicine·Jason H Moore, Scott M Williams
Sep 6, 2002·The Journal of Clinical Endocrinology and Metabolism·Pitt O LimJohn M C Connell
Dec 7, 2002·Hypertension·Dongfeng GuUNKNOWN InterASIA Collaborative Group. The International Collaborative Study of Cardiovascular Disease in ASIA
Feb 18, 2003·Current Opinion in Nephrology and Hypertension·Pedro A JoseRobin A Felder
Aug 20, 2003·Hypertension·Stephen B HarrapUNKNOWN PROGRESS Collaborative Group
Apr 30, 2004·Statistics in Medicine·Nancy R CookPaul M Ridker
May 1, 2004·Hypertension·Friedrich C Luft
May 11, 2004·Human Heredity·Scott M WilliamsJason H Moore
Nov 19, 2004·Physiological Genomics·Chunyu ZengPedro A Jose

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Citations

Jan 12, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Qi ZhaoDongfeng Gu
Aug 13, 2008·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Masaaki KuribayashiToshikazu Kubo
Nov 9, 2010·Current Hypertension Reports·Hironobu SanadaPedro A Jose
Aug 27, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yuqing LouShaojun Wen
Oct 27, 2006·Nature Clinical Practice. Nephrology·Robin A Felder, Pedro A Jose
Jan 31, 2008·European Journal of Human Genetics : EJHG·Hui-Yi LinSeng-jaw Soong
May 28, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Anna StecMonika Buraczynska
Jul 22, 2008·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Amy K MottlKari E North
Feb 20, 2007·Annual Review of Physiology·Richard T Premont, Raul R Gainetdinov
Mar 19, 2008·Hypertension·Chunyu ZengPedro A Jose
Oct 30, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Junichi YatabePedro A Jose
Apr 26, 2008·PLoS Computational Biology·Liping Wei, Jun Yu
Jul 27, 2011·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Samantha J LuptonJoanne M Lind
May 29, 2012·International Journal of Medical Sciences·Chibo Liu, Bo Xi
Apr 7, 2007·Current Opinion in Cardiology·Alexander Binder
Nov 28, 2009·Cellular and Molecular Life Sciences : CMLS·Bhavani S SahuNitish R Mahapatra
Jul 29, 2010·Clinical and Experimental Hypertension : CHE·Xiaoshu Cheng, Gaosi Xu
Sep 13, 2015·Clinical and Experimental Hypertension : CHE·Wei GuShaojun Wen
Dec 21, 2010·Clinical and Translational Science·Maria P Martinez CantarinBonita Falkner
Feb 16, 2010·Biochimica Et Biophysica Acta·Pedro A JoseRobin A Felder
Nov 26, 2014·The Pharmacogenomics Journal·A AdefurinD Kurnik
Feb 21, 2009·American Journal of Hypertension·Brian J Morris
Nov 22, 2008·American Journal of Hypertension·Paolo PalatiniAndrea Semplicini
Feb 19, 2011·American Journal of Hypertension·Chong ShenDongfeng Gu
Oct 23, 2010·American Journal of Hypertension·Giulio CeolottoAndrea Semplicini

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