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Association testing of clustered rare causal variants in case-control studies

PloS One

Apr 15, 2014

Wan-Yu Lin

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Abstract

Biological evidence suggests that multiple causal variants in a gene may cluster physically. Variants within the same protein functional domain or gene regulatory element would locate in close proximity on the DNA sequence. However, spatial information of variants is usually not used in...read more

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  • Association testing of clustered rare causal variants in case-control studies

    PloS One

    Apr 15, 2014

    Wan-Yu Lin

    PMID: 24736372

    DOI: 10.1371/journal.pone.0094337

    Abstract

    Biological evidence suggests that multiple causal variants in a gene may cluster physically. Variants within the same protein functional domain or gene regulatory element would locate in close proximity on the DNA sequence. However, spatial information of variants is usually not used in...read more

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    Paper Details
    References
    • References37
    • Citations11
    • References37
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