Association with Genetic Variants in the IL-23 and NF-κB Pathways Discriminates between Mild and Severe Psoriasis Skin Disease

The Journal of Investigative Dermatology
Pernilla NikamoMona Ståhle

Abstract

Psoriasis is clinically heterogeneous, and symptoms can vary from mild almost cosmetic symptoms to severe disease requiring systemic therapy. Biomarkers predicting disease development are lacking. Herein we explored the genetic background in two polarized cohorts of carefully phenotyped patients with long-term follow-up: consistent mild phenotype (n=696) and severe disease course requiring systemic therapy (n=715). All patients were treated at the same dermatology department ensuring homogenous assessment. Genotyping included known psoriasis-associated variants, with special focus on the IL-23 and NF-κB pathways. A case-case study comparing severe and mild psoriasis phenotypes, controlling for age at disease onset and gender, revealed significant differences between the two groups for SNPs in IL23R, NFKB1, IL21, IL12B, NFKBIL1 and IL23A. HLA-C*06 associated equally in the mild and severe disease cohorts. Strong additive effects when combining HLA-C*06 with IL23A, IL23R, IL12B, NFKB1 or TNIP1 were restricted to the severe cohort, indicating that activation of these pathways may influence disease severity in psoriasis. No protective gene was identified in the mild cohort, suggesting that current screens have primarily identified ...Continue Reading

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Citations

Nov 10, 2015·Expert Opinion on Pharmacotherapy·Ki-Wei Tan, Christopher Em Griffiths
Jul 16, 2015·The Journal of Investigative Dermatology·Erin Wei, Mariya Miteva
Mar 19, 2016·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Kun-Qi YangXian-Liang Zhou
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Jun 28, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·G GirolomoniJ C Prinz
Apr 24, 2019·Archives of Dermatological Research·Zita Szentkereszty-KovácsDániel Törőcsik
Mar 1, 2019·Molecular Medicine Reports·Jianjun YanQing Sun
Dec 20, 2020·Molecular Genetics & Genomic Medicine·Pardis-Sadat Tabatabaei-PanahReza Akbarzadeh
Jan 2, 2021·Journal of Personalized Medicine·Dmitry A VerbenkoAlexey A Kubanov
Apr 15, 2021·JAMA Dermatology·Axel SvedbomMona Ståhle
Jul 24, 2021·The Journal of Investigative Dermatology·Jörg Christoph Prinz

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