Associations among amino acid, lipid, and glucose metabolic profiles in childhood obesity

BMC Pediatrics
Yosuke SuzukiKimitoshi Nakamura

Abstract

Plasma-free amino acid profiles have been reported to correlate with obesity and glucose metabolism, and have been studied as potentially useful biomarkers of lifestyle-related diseases affecting metabolism in adulthood. However, knowledge of these relationships is lacking in children, despite the growing public health problem posed by childhood obesity. The aim of this study was to assess whether plasma-free amino acid profiles can serve as useful biomarkers of lifestyle-related diseases in children with obesity. This retrospective study used the medical records of 26 patients (15 male, 11 female) aged 9 or 10 years presenting with moderate to severe obesity and hyperlipidemia between April 2015 and March 2017. A degree of obesity of 30% or more was defined as moderate or severe. Amino acid levels were compared between obese children with and without impaired glucose tolerance using a t-test or Mann-Whitney U test. In addition, the influence of factors such as intima media thickness, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, amino acids, and homeostasis model assessment-insulin resistance (HOMA-IR) were analyzed pairwise using Pearson's correlation or Spearman's rank correlation. HOMA-IR was po...Continue Reading

References

Oct 29, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·D S FreedmanG S Berenson
Nov 6, 2003·JAMA : the Journal of the American Medical Association·Olli T RaitakariJorma S A Viikari
Sep 29, 2004·Diabetes Care·Arcangelo IannuzziMaurizio Trevisan
Dec 6, 2005·Metabolism: Clinical and Experimental·Thomas ReinehrRanier Wunsch
Mar 9, 2006·The Journal of Clinical Endocrinology and Metabolism·Janet LoSteven K Grinspoon
Jan 30, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·D S FreedmanG S Berenson
Mar 12, 2008·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A S SinghM J M Chinapaw
Mar 23, 2011·Nature Medicine·Thomas J WangRobert E Gerszten
Jun 4, 2011·Molecular Genetics and Metabolism·Taiga MochidaFumio Endo
May 9, 2012·Diabetes Care·Peter WürtzMika Ala-Korpela
Apr 2, 2015·Nature Communications·Noriaki ShimizuHirotoshi Tanaka
May 5, 2016·The Journal of Nutritional Biochemistry·Harald ManggeAndreas Meinitzer
Oct 4, 2018·The New England Journal of Medicine·Mandy GeserickAntje Körner

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Citations

Jul 29, 2020·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Caixia YanYan Liang
Dec 8, 2020·Archives of Physiology and Biochemistry·Monika RiedererMoenie van der Kleyn

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