Associations among diet, the gastrointestinal microbiota, and negative emotional states in adults.

Nutritional Neuroscience
Andrew M TaylorHannah D Holscher

Abstract

Objective: Habitual diet impacts mood and the human gastrointestinal (GI) microbiota. Yet, studies infrequently control for diet when evaluating associations between mood and GI microbiota. Accordingly, we aimed to investigate relationships among diet, GI microbiota, and mood in adults without mood disorders by conducting a cross-sectional examination of dietary intake, subjective emotional state, and fecal microbial taxa abundances. Methods: Adults (N = 133; 25-45 years of age) without physician-diagnosed mood disorders were studied. Fecal DNA was extracted, and the V4 region of the 16S rRNA gene was sequenced. Sequences were analyzed using QIIME2. Subjective mood state was assessed using the 42-item Depression, Anxiety, and Stress Scale (DASS-42). Habitual dietary intake was measured with the National Cancer Institute's Diet History Questionnaire II, and diet quality was evaluated with the 2010 Healthy Eating Index (HEI). Results: Relationships were observed between 28 bacterial taxa and DASS-42 scores. Sex-dependent associations were observed among 21 bacterial taxa and DASS-42 scores, including an inverse relationship between Anxiety scale scores and Bifidobacterium in females and an inverse relationship between Depression ...Continue Reading

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Citations

Aug 29, 2019·Physiological Reviews·John F CryanTimothy G Dinan
Nov 25, 2019·The International Journal of Neuropsychopharmacology·Shan LiChun Yang
Jun 19, 2020·Nutrients·Noemí Redondo-UserosAscensión Marcos
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Mar 7, 2021·International Journal of Molecular Sciences·Hae Jeong ParkJong Woo Kim
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Jul 13, 2021·Frontiers in Psychiatry·Faezeh SaghafianPeyman Adibi
Nov 10, 2021·Current Opinion in Psychiatry·Kirsten Berding, John F Cryan

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