Associations among histological characteristics and patient outcomes in colorectal carcinoma with a mucinous component

Histopathology
Raul S GonzalezKay Washington

Abstract

Colorectal carcinoma (CRC) often has a mucinous component, with more than 50% mucin by volume defining the mucinous subtype of CRC. The prognostic impact of the mucinous phenotype remains unclear. We evaluated 224 CRC with at least 5% mucinous component (herein 'mCRC') for patient sex, age, race and outcome; tumour size, location, stage and microsatellite instability (MSI) status; percentage of glands producing mucin; percentage of tumour volume composed of mucin; whether tumoral epithelium floated in mucin pools; tumour budding; signet ring cells (SRCs); and peritumoural inflammation (PI). We related these features to disease-specific survival and compared outcomes to 499 stage-matched, conventional colorectal adenocarcinomas. Factors predicting worse prognosis in mCRC on univariable analysis included non-MSI-high status (P = 0.0008), SRC (P = 0.0017) and lack of PI (P = 0.0034). No parameters were independently associated with outcome after adjusting for tumour stage in multivariate analysis. The percentage of glands producing mucin and percentage tumour volume composed of mucin did not affect prognosis, including at the recommended 50% cut-off for subtyping mCRC. Disease-specific survival for mCRC and adenocarcinomas were si...Continue Reading

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Citations

Feb 13, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·David S WilliamsOliver M Sieber
Nov 5, 2020·Cancers·Matthew G K Benesch, Alexander Mathieson
Aug 11, 2020·Surgical Pathology Clinics·Melanie Johncilla, Rhonda K Yantiss
Jun 26, 2021·Cancer Management and Research·Qing HuangJie Cao
Jun 4, 2021·Applied Immunohistochemistry & Molecular Morphology : AIMM·Xiaoli JiaZhe Yan

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