Associations between adverse perinatal outcome and serially obtained second- and third-trimester maternal serum alpha-fetoprotein measurements

American Journal of Obstetrics and Gynecology
J L SimpsonSherman Elias

Abstract

Our purpose was to determine whether third-trimester maternal serum alpha-fetoprotein predicts adverse perinatal outcome and whether use of both second- and third-trimester maternal serum alpha-fetoprotein enhances the positive predictive value for various abnormal outcomes. A cohort study with obstetric outcome assessed by chart analysis after delivery was performed at Regional Medical Center (Memphis, Tennessee), a hospital staffed by university-based physicians serving a large urban population with many indigent patients. A total of 650 women attending prenatal clinics in the above setting with a singleton pregnancy without a neural tube defect, contributing a maternal blood samples in both the second and third trimesters, and delivered in the above hospital participated. Various pregnancy outcomes were correlated with maternal serum alpha-fetoprotein levels in the second and third trimesters and in both. In the third trimester no significant associations were found between maternal serum alpha-fetoprotein elevations and pregnancy complications. In the second trimester elevation ( > or = 2.0 multiples of the median) were, by contrast, significantly associated with preterm premature rupture of the membranes, preterm birth, an...Continue Reading

Citations

Dec 2, 2004·Obstetrics and Gynecology·Agustin Conde-AgudeloMarshall Lindheimer
Dec 31, 2014·Archives of Gynecology and Obstetrics·Pongsun PuntachaiTheera Tongsong
Aug 4, 2007·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Shad H DeeringAlessandro Ghidini
Mar 18, 2011·Fetal Diagnosis and Therapy·Jarek BetaKypros H Nicolaides

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