Associations Between Ambient Air Pollutant Concentrations and Birth Weight: A Quantile Regression Analysis

Epidemiology
Matthew J StricklandHoward H Chang

Abstract

We investigated the extent to which associations of ambient air pollutant concentrations and birth weight varied across birth weight quantiles. We analyzed singleton births ≥27 weeks of gestation from 20-county metropolitan Atlanta with conception dates between January 1, 2002 and February 28, 2006 (N = 273,711). Trimester-specific and total pregnancy average concentrations for 10 pollutants, obtained from ground observations that were interpolated using 12-km Community Multiscale Air Quality model outputs, were assigned using maternal residence at delivery. We estimated associations between interquartile range width (IQRw) increases in pollutant concentrations and changes in birth weight using quantile regression. Gestational age-adjusted associations were of greater magnitude at higher percentiles of the birth weight distribution. Pollutants with large vehicle source contributions (carbon monoxide, nitrogen dioxide, PM2.5 elemental carbon, and total PM2.5 mass), as well as PM2.5 sulfate and PM2.5 ammonium, were associated with birth weight decreases for the higher birth weight percentiles. For example, whereas the decrease in mean birthweight per IQRw increase in PM2.5 averaged over pregnancy was -7.8 g (95% confidence interv...Continue Reading

References

Feb 1, 2002·International Journal of Epidemiology·A J Wilcox
Aug 26, 2006·American Journal of Epidemiology·Sonia Hernández-DíazMiguel A Hernán
Jan 29, 2008·European Journal of Epidemiology·Sonia Hernández-DíazMiguel A Hernán
Apr 1, 2014·Journal of Epidemiology and Community Health·Sissi CaoJoel G Ray
Mar 13, 2015·Biometrics·Luke B SmithMontserrat Fuentes
Jan 23, 2016·Environmental Health and Toxicology·Dirga Kumar LamichhaneHwan-Cheol Kim
Dec 15, 2016·Journal of Exposure Science & Environmental Epidemiology·Audrey Flak PenningtonLyndsey A Darrow
Dec 6, 2017·American Journal of Epidemiology·Ander WilsonBrent A Coull

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Citations

Jun 3, 2020·International Journal of Environmental Research and Public Health·David OlssonBertil Forsberg
Feb 3, 2021·Biostatistics·Daniel Mork, Ander Wilson
Mar 30, 2021·American Journal of Epidemiology·Joshua D AlampiLawrence C McCandless

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