Associations between anti-Ro52 antibodies and lung fibrosis in mixed connective tissue disease

Rheumatology
Ragnar GunnarssonØyvind Molberg

Abstract

MCTD is a chronic, immune-mediated disorder defined by the combined presence of serum anti-RNP antibodies and distinct clinical features, including progressive lung fibrosis. The aim of the study was to evaluate the potential impact of anti-SSA (i.e. Ro52 and Ro60) and anti-SSB autoantibodies as markers for disease outcomes in MCTD. Stored serum samples from 113 patients included in the cross-sectional, nationwide Norwegian MCTD cohort were screened for the presence of anti-Ro52, anti-Ro60 and anti-SSB by a commercial line immunoassay. Correlation analyses were carried out with clinical parameters, including quantitative lung fibrosis scores by high-resolution CT. Lung fibrosis was defined by reticular pattern changes according to the Fleischner Society CT criteria for interstitial lung disease. Anti-Ro52 antibodies were present in 29%, anti-Ro60 in 19% and anti-SSB in 6% of the MCTD sera. High-resolution CT scoring identified lung fibrosis in 38 of 113 (34%) MCTD patients. Anti-Ro52 antibodies were detected in 50% (19 of 38) of the MCTD patients with lung fibrosis and in 19% (14 of 75) without lung fibrosis (P < 0.001). The odds ratio for the presence of anti-Ro52 antibodies in lung fibrosis was 4.4 (95% CI 1.8, 10.3). Anti-Ro...Continue Reading

References

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Citations

Jul 17, 2016·Best Practice & Research. Clinical Rheumatology·Ragnar GunnarssonØyvind Molberg
Dec 6, 2017·Expert Review of Clinical Immunology·Fabiola AtzeniPiercarlo Sarzi-Puttini
Jun 7, 2019·Tuberculosis and Respiratory Diseases·So My KooUNKNOWN Korean Interstitial Lung Diseases Study Group
Apr 2, 2016·Current Rheumatology Reports·Roberta A Berard, Ronald M Laxer
Jul 2, 2019·NeoReviews·Leander D TimothyGarth F Asay
Oct 13, 2020·Journal of Clinical Biochemistry and Nutrition·Hiroko MoritaKazuhiro Kurasawa
Aug 16, 2019·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Raphael LhoteFleur Cohen Aubart
Jan 19, 2021·Seminars in Arthritis and Rheumatism·Nancy MaltezUNKNOWN Canadian Scleroderma Research Group
Oct 23, 2020·Clinical Case Reports·Safa RahmouniWafa Hamdi
Feb 15, 2020·Respiratory Medicine·Charlotte BuvryVincent Grobost
May 12, 2021·European Journal of Internal Medicine·Paul DeckerRoland Jaussaud
Jul 11, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Dimitrios P BogdanosChristos Papandreou
Aug 12, 2021·Therapeutic Advances in Musculoskeletal Disease·Masataka KuwanaAlbert Selva-O'Callaghan

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