Associations between antioxidant vitamins and the risk of invasive cervical cancer in Chinese women: A case-control study

Scientific Reports
Liyuan GuoDongwei Mao

Abstract

Previous studies on the associations between dietary antioxidant vitamins and the risk of cervical cancer remain inconsistent, and little evidence is available for serum antioxidant vitamins, which provide more accurate measurements of these nutrients. We conducted a case-control study of 458 incident cases with invasive cervical cancer and 742 controls to assess the effects of diet or serum antioxidant vitamins. Higher serum antioxidant vitamins were associated with a lower risk of cervical cancer after adjusting for potential confounders. The odds ratios (ORs) for the highest (vs. lowest) quartile were 0.66 (95% confidence interval [CI] = 0.46-0.93; P = 0.024) for α-carotene, 0.63 (95% CI = 0.45-0.90; P = 0.006) for β-carotene, 0.53 (95% CI = 0.37-0.74; P < 0.001) for vitamin E, and 0.48 (95% CI = 0.33-0.69; P < 0.001) for vitamin C. Dietary intakes of vitamins E and C were inversely associated with the risk of cervical cancer. Risk of cervical cancer from serum antioxidant vitamins was more evident in passive smokers than non-passive smokers. These findings indicated that antioxidant vitamins (mainly α-carotene, β-carotene, and vitamins E and C) might be beneficial in reducing the risk of invasive cervical cancer in Chinese ...Continue Reading

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Citations

Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Sumit KumarRamovatar Meena
Oct 30, 2016·British Journal of Pharmacology·Alireza MilaniAzam Bolhassani
Aug 30, 2020·Cancers·Lenka KoklesovaPeter Kubatka
Jun 27, 2019·Journal of Environmental and Public Health·Maria Teresa SchettinoEzgi Hanci Yenigün
Oct 31, 2020·Nutrition and Cancer·Amber NareshJennifer Cameron
May 1, 2021·Nutrients·Michał CiebieraMohamed Ali

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