Associations between apolipoprotein B, apolipoprotein AI, the apolipoprotein B/AI ratio and coronary heart disease: a literature-based meta-analysis of prospective studies

Journal of Internal Medicine
A Thompson, John Danesh

Abstract

To assess associations of circulating levels of apolipoprotein (apo) AI, apoB and the apoB/AI ratio (apoB/A) with risk of incident coronary heart disease (CHD). Literature-based meta-analysis of prospective studies. Prospective studies in essentially general populations that reported on associations between apoAI, apoB or apoB/A and first incident CHD outcomes. Studies were identified by computer-based searches and by manual searches of the relevant literature. Data from 23 relevant studies were identified. For apoAI, with 6333 CHD cases in 21 studies, comparison of individuals in the bottom third with those in the top third of baseline values yielded a combined relative risk of 1.62 (95% confidence interval: 1.43-1.83), i.e. an inverse association. For apoB, a combined analysis of 6320 CHD cases from 19 studies gave a relative risk of 1.99 (1.65-2.39) for a comparison of individuals in the top third versus those in the bottom third of baseline values. For apoB/A, with 3730 CHD cases from seven studies, a comparison of individuals in the top third versus the bottom third of baseline values gave a combined relative risk of 1.86 (1.55-2.22). These associations were somewhat stronger following correction for within-person variatio...Continue Reading

References

Jun 1, 1978·European Journal of Clinical Investigation·T IshikawaN E Miller
May 1, 1992·European Journal of Epidemiology·G Assmann, H Schulte
May 15, 1992·The American Journal of Cardiology·G SigurdssonN Sigfusson
Aug 8, 1991·The New England Journal of Medicine·M J StampferC H Hennekens
Nov 1, 1993·European Journal of Epidemiology·E CasigliaG B Ambrosio
Aug 1, 1996·Arteriosclerosis, Thrombosis, and Vascular Biology·S KataokaB V Howard
Nov 13, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·L MykkänenM A Austin
Dec 15, 2000·European Journal of Clinical Investigation·P M SweetnamJ W Yarnell
Jan 12, 2001·The American Journal of Medicine·M SeedG J Miller
Oct 26, 2002·JAMA : the Journal of the American Medical Association·UNKNOWN Homocysteine Studies Collaboration
Nov 7, 2002·The American Journal of Cardiology·Allan D Sniderman
Nov 12, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Philippa J TalmudSteve E Humphries
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
May 4, 2004·Atherosclerosis. Supplements·Allan SnidermanNaveed Sattar
May 29, 2004·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Anna M ThøgersenGöran Hallmans
Jul 17, 2004·International Journal of Epidemiology·Bernard KeavneyUNKNOWN International Studies of Infarct Survival (ISIS) Collaborators

❮ Previous
Next ❯

Citations

Mar 8, 2011·International Archives of Occupational and Environmental Health·Kirsten Nabe-NielsenFinn Diderichsen
Aug 12, 2006·Current Atherosclerosis Reports·Natalie Khuseyinova, Wolfgang Koenig
Jan 5, 2008·Current Atherosclerosis Reports·Allan D Sniderman, Robert S Kiss
Oct 5, 2011·Current Cardiology Reports·Beatriz G Talayero, Frank M Sacks
Nov 7, 2007·Nature Clinical Practice. Cardiovascular Medicine·Justo Sierra-Johnson, Rachel M Fisher
Dec 24, 2010·European Heart Journal·Catherine McGorrianUNKNOWN INTERHEART Investigators
Feb 13, 2008·International Journal of Epidemiology·Eero KajantieJohan G Eriksson
Jan 12, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Per-Ola AttmanPetar Alaupovic
Sep 24, 2009·Vascular Health and Risk Management·Jesús MillánJuan Pedro-Botet
Sep 30, 2009·Nutrition Reviews·Surabhi Bhutani, Krista A Varady
Jul 31, 2013·Expert Opinion on Investigational Drugs·Paul Lee, Robert A Hegele
Nov 16, 2013·The American Journal of Cardiology·Hisato TakagiUNKNOWN ALICE (All-Literature Investigation of Cardiovascular Evidence) Group
May 18, 2011·Fertility and Sterility·Chung-Yu ChangJuin-Huang Su
Oct 1, 2010·Atherosclerosis·David L RainwaterMichael C Mahaney
Dec 1, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hung-Yu SunKung-Chia Young
Jan 13, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Alvaro CerdaRosario D C Hirata
Jan 27, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hind BerrahmouneSophie Visvikis-Siest
Dec 17, 2008·American Heart Journal·Michal BenderlyUri Goldbourt
Oct 15, 2008·Biochemical Pharmacology·Ivanise Marina Moretti RebecchiRosario Dominguez Crespo Hirata
Dec 15, 2007·Metabolism: Clinical and Experimental·Maria Claudia Peixoto CenciMario Vaisman
Mar 11, 2008·Journal of the Cardiometabolic Syndrome·Justo Sierra-JohnsonFrancisco Lopez-Jimenez
Feb 24, 2012·Diabetic Medicine : a Journal of the British Diabetic Association·Y C HwangS W Park
Dec 12, 2012·Journal of Gastroenterology and Hepatology·Young Gil ChoeByung Ik Kim
Dec 18, 2012·International Journal of Clinical Practice·S Martinez-HervasJ F Ascaso
Jul 4, 2013·Diabetic Medicine : a Journal of the British Diabetic Association·Y-C HwangC-Y Park
Jul 29, 2010·Clinical Physiology and Functional Imaging·L Vladimirova-KitovaB Marinov
Apr 20, 2010·Journal of the American Geriatrics Society·Chandra A ReynoldsNancy L Pedersen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.