Associations between apparent diffusion coefficient and electromyography parameters in myositis-A preliminary study

Brain and Behavior
Hans-Jonas MeyerAlexey Surov

Abstract

MRI is widely used in several muscle disorders. Diffusion-weighted imaging (DWI) is an emergent imaging modality sensitive to microstructural alterations in tissue. The apparent diffusion coefficient (ADC) is used to quantify the random motion of water molecules. Electromyography (EMG) is a clinically used diagnostic tool in myositis. The aim of this study was to elucidate possible associations between ADC values and EMG findings in myositis patients. Seven patients (eight investigated muscles) with myositis (mean age 51.43 ± 19 years) were included in this study. The diagnosis was confirmed by histopathology in every case. DWI was obtained with a 1.5-T scanner using two b-values 0 and 1000 s/mm². In all patients, a needle electromyography (EMG) was performed within 3 days to the MRI. The following EMG parameters were studied: motor unit action potential (MUAP) amplitudes and durations, as well as pathological spontaneous activity. Spearman's correlation coefficient was used to analyze associations between investigated parameters. The estimated mean ADC mean value was 1.51 ± 0.29 × 10-3 mm²/s, mean ADC min was 1.28 ± 0.27 × 10-3 mm²/s, and mean ADC max was 1.73 ± 0.28 × 10-3 mm²/s. Correlation analysis identified significant as...Continue Reading

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Citations

May 22, 2020·Acta Neurologica Scandinavica·Hans-Jonas MeyerAlexey Surov
Aug 28, 2020·Current Rheumatology Reports·K KubínováJiří Vencovský
Oct 18, 2018·Journal of Clinical Medicine·Alexey SurovAndreas Wienke
May 28, 2021·Brain Pathology·Samuel MalartreYves Allenbach
Jun 12, 2021·International Journal of Endocrinology·Amira Mohammed Ali, Hiroshi Kunugi

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Methods Mentioned

BETA
biopsy

Software Mentioned

GraphPad
GraphPad Prism

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