Associations Between Carotid Artery Plaque Burden, Plaque Characteristics, and Cardiovascular Events: The ARIC Carotid Magnetic Resonance Imaging Study.

JAMA Cardiology
Gerd BrunnerBruce A Wasserman

Abstract

It remains unknown whether in an asymptomatic community-based cohort magnetic resonance imaging (MRI) measures of plaque characteristics are independently associated with incident cardiovascular disease (CVD) events when adjusted for carotid artery (CA) wall thickness, a measure of plaque burden. To assess associations of CA MRI plaque characteristics with incident CVD events. The Atherosclerosis Risk in Communities (ARIC) study is a prospective epidemiologic study of the incidence of CVD in 15 792 adults of which 2066 women and men were enrolled in the ARIC Carotid MRI substudy. ARIC participants were enrolled from 1987 to 1989, and the substudy was conducted between January 2004 and December 2005. Analysis began January 2017 and ended August 2020. Incident CVD events during a median (interquartile range [IQR]) follow-up time of 10.5 (8.1-10.9) years were assessed. Proportional hazards Cox analyses were performed to ascertain associations between MRI variables of CA plaque burden and plaque characteristics. Of 15 792 ARIC participants, 2066 were enrolled in the substudy, of whom 1256 (701 women [55.8%]) had complete data and were eligible for incident CVD analyses. Carotid artery plaques in participants with incident CVD event...Continue Reading

References

Jan 1, 1996·Lifetime Data Analysis·J K Grønnesby, O Borgan
Dec 12, 2003·The New England Journal of Medicine·Frank D KolodgieRenu Virmani
Jul 23, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Renu VirmaniJagat Narula
Aug 26, 2006·Stroke; a Journal of Cerebral Circulation·Tetsuya OhiraAaron R Folsom
Feb 7, 2008·JAMA : the Journal of the American Medical Association·Willem E HellingsGerard Pasterkamp
Apr 28, 2009·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Venkatesh ManiZahi A Fayad
Oct 8, 2009·Circulation. Cardiovascular Imaging·Lynne WagenknechtEric Boerwinkle
Apr 26, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Yiyi ZhangBruce A Wasserman
Aug 9, 2015·Diabetes Care·Saula Vigili de KreutzenbergAngelo Avogaro

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