Associations between cigarette smoking, hormone therapy, and folate intake with incident colorectal cancer by TP53 protein expression level in a population-based cohort of older women

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Lori S TillmansPaul J Limburg

Abstract

Cigarette smoking (CS), hormone therapy (HT), and folate intake (FI) are each thought to influence colorectal cancer risk, but the underlying molecular mechanisms remain incompletely defined. The TP53 (p53) protein, encoded by the TP53 tumor-suppressor gene that is commonly mutated in colorectal cancer, can be readily assessed to differentiate biologically distinct colorectal cancer subtypes. In this prospective cohort study, we examined CS-, HT-, and FI-associated colorectal cancer risks by TP53 protein expression level among Iowa Women's Health Study (IWHS) participants. The IWHS recruited 41,836 randomly selected Iowa women, ages 55 to 69 years, with a valid driver's license at study entry in 1986. Self-reported exposure variables were assessed at baseline. Incident colorectal cancer cases were ascertained by annual linkage with the Iowa Cancer Registry. Archived, paraffin-embedded tissue specimens were collected and evaluated for TP53 protein expression by immunohistochemistry. Multivariate Cox regression models were fit to estimate relative risks (RR) and 95% confidence intervals (CI) for associations between CS, HT, or FI and TP53-defined colorectal cancer subtypes. Informative environmental exposure and protein expressio...Continue Reading

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Citations

Nov 26, 2015·Journal of the National Cancer Institute·Kentaro InamuraShuji Ogino
Jul 30, 2020·Cancers·Isabella GiganteMaria Notarnicola
Mar 10, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kosuke MimaShuji Ogino
Feb 5, 2015·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Lori S TillmansPaul J Limburg
Aug 17, 2021·Journal of the Anus, Rectum and Colon·Kyoichi KiharaYoshiyuki Fujiwara
Jul 16, 2021·Journal of the National Cancer Institute·Tomotaka UgaiShuji Ogino

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